2024
Lifetime history of childhood adversity and substance abuse in patients with treatment resistant depression
Giampetruzzi E, McDonald W, Rice H, Kitay B, Hermida A, Posse P, Hershenberg R. Lifetime history of childhood adversity and substance abuse in patients with treatment resistant depression. Personalized Medicine In Psychiatry 2024, 43: 100122. DOI: 10.1016/j.pmip.2024.100122.Peer-Reviewed Original ResearchTreatment-resistant depressionAdverse childhood experiencesHistory of substance abuseSubstance abuseDepressive disorderAssociated with treatment-resistant depressionTreatment-resistant depressed patientsPersistent depressive disorderLifetime substance abuseEffects of adverse childhood experiencesRisk of substance abuseAssociation of adverse childhood experiencesACE subtypesACE exposureResistant depressionLifetime historyChildhood adversityChildhood experiencesAbuseClinical samplesDepressionDisordersLogistic regression analysisMDDSubstancesChapter 19 Deep brain stimulation for depression
Kitay B, Riva-Posse P. Chapter 19 Deep brain stimulation for depression. 2024, 451-478. DOI: 10.1016/b978-0-443-18496-3.00019-7.Peer-Reviewed Original ResearchMajor depressive disorderTreatment-refractory depressionObsessive-compulsive disorderDeep brain stimulationBrain stimulationTarget of deep brain stimulationAntidepressant therapyDepressive disorderNeuropsychiatric disordersClinical psychiatryDepressionDisordersMovement disordersNetwork hypothesisPsychotherapyTherapeutic optionsSurgical interventionPsychiatryNeuromodulation technologyStimulationEpilepsyInterventionHypothesisTechnical advancesPharmacology
2023
P1: Dosing and treatment outcomes of rTMS for treatment-resistant depressed older adults in a naturalistic outpatient clinic population.
Tan A, Patricia A, Hershenberg R, Chatham A, Giampetruzzi E, Tsygankova V, Job G, Crowell A, Posse P, McDonald W, Kitay B. P1: Dosing and treatment outcomes of rTMS for treatment-resistant depressed older adults in a naturalistic outpatient clinic population. International Psychogeriatrics 2023, 35: 191-192. DOI: 10.1017/s1041610223003368.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationTreatment-resistant depressionWithin-group reductionsAnxiety scoresAnxiety symptom severityGroup 2Repetitive transcranial magnetic stimulation studiesGroup 1Depressed older adultsCognitive side effectsSelf-reported depressionEffects of repetitive transcranial magnetic stimulationReduction of depressionOlder adultsReduction of anxietyInternational meta-analysesAdult patientsRetrospective chart review of patientsChart review of patientsOutpatient sampleAnxiety symptomsResponse rateTranscranial magnetic stimulationDepressive symptomsNon-older patients
2019
The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion
Kitay BM, Katz RB, Wilkinson ST, Ostroff RB. The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion. Journal Of Ect 2019, 35: e4-e5. PMID: 29952859, PMCID: PMC6309946, DOI: 10.1097/yct.0000000000000516.Peer-Reviewed Original Research
2018
50 Studies Every Psychiatrist Should Know
Chapter 18: Memantine in Patients with Moderate to Severe Alzheimer Disease Already Receiving Donepezil. Brandon M. Kitay and Rajesh R. Tampi; Chapter 29: Exposure and Ritual Prevention, Clomipramine, or Their Combination for Obsessive-Compulsive Disorder. Brandon M. Kitay and Michael H. BlochBooks
2013
Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria
Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG. Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria. Human Molecular Genetics 2013, 22: 1601-1614. PMID: 23314018, PMCID: PMC3657477, DOI: 10.1093/hmg/ddt009.Peer-Reviewed Original ResearchConceptsDrosophila larval motor neuronsLarval motor neuronsAxonal mitochondriaRole of mitochondriaEvolutionary conservationMN axonsMorphological comparisonMotor neuronsMitochondriaMolecular pathwaysAxon protectionNeuronal mitochondriaWallerian degenerationNeurodegenerative diseasesCentral roleIntense investigationDistal axonsRegulationMorphological changesDorsal root ganglion explantsAxon degenerationHuman DRG neuronsCritical sitesUnderlying mechanismMislocalization
2010
Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration
Ali YO, Kitay BM, Zhai RG. Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration. Molecules 2010, 15: 6859-6887. PMID: 20938400, PMCID: PMC3133442, DOI: 10.3390/molecules15106859.Peer-Reviewed Original ResearchConceptsMolecular chaperonesMisfolded proteinsNormal protein homeostasisRepair of proteinsProtein-protein interactionsHuman neurodegenerative diseasesNeurodegenerative diseasesNascent proteinsProtein homeostasisNetwork of moleculesCellular functionsConformational diseasesProteolytic machineryProtein speciesCellular stressChaperonesClearance of proteinsNormal proteinProteinFunctional classificationSuch diseasesFoldingEnvironmental factorsWide arrayTherapeutic potential
2007
Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery
Pearse DD, Sanchez AR, Pereira FC, Andrade CM, Puzis R, Pressman Y, Golden K, Kitay BM, Blits B, Wood PM, Bunge MB. Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery. Glia 2007, 55: 976-1000. PMID: 17526000, DOI: 10.1002/glia.20490.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsBrain Tissue TransplantationCell CommunicationCell MovementCell SurvivalFemaleGenetic MarkersGenotypeGraft SurvivalGreen Fluorescent ProteinsMaleNeural PathwaysOlfactory BulbRatsRats, Inbred F344Recovery of FunctionSchwann CellsSpinal Cord InjuriesTreatment OutcomeY ChromosomeConceptsContused spinal cordSchwann cellsSpinal cordFunctional recoveryAdult rat spinal cordGrafted Schwann cellsSpinal cord injury repairRat spinal cordLentiviral vector-mediated expressionNumerous myelinated axonsLong-term markersVector-mediated expressionInjury milieuHost axonsMale transplantsGrafted cellsFemale ratsInjury siteCentral canalInjury repairY chromosome-specific probesMyelinated axonsSurvival rateLesionsTransplanted cellsSchwann Cell Transplantation Improves Reticulospinal Axon Growth and Forelimb Strength after Severe Cervical Spinal Cord Contusion
Schaal SM, Kitay BM, Cho KS, Lo TP, Barakat DJ, Marcillo AE, Sanchez AR, Andrade CM, Pearse DD. Schwann Cell Transplantation Improves Reticulospinal Axon Growth and Forelimb Strength after Severe Cervical Spinal Cord Contusion. Cell Transplantation 2007, 16: 207-228. PMID: 17503734, DOI: 10.3727/000000007783464768.Peer-Reviewed Original ResearchConceptsSpinal cord injuryAxon growthNeuroprotective efficacyCervical spinal cord contusionInjury/graft siteCell bodiesThoracic spinal cord injurySchwann cell transplantationSpinal cord contusionThoracic spinal cordAdult female Fischer ratsFemale Fischer ratsSchwann cell implantationUpper limb strengthSignificant behavioral improvementCervical contusionInjury epicenterCord contusionUpper body strengthWeeks postinjuryBBB scoresSC implantsSupraspinal axonsCell transplantationCord injury
2005
Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue.
Blits B, Kitay BM, Farahvar A, Caperton CV, Dietrich WD, Bunge MB. Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue. Restorative Neurology And Neuroscience 2005, 23: 313-24. PMID: 16477093.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InjuriesCell MovementCells, CulturedDisease Models, AnimalEmbryo, MammalianFemaleGenetic VectorsGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsImmunohistochemistryIntermediate Filament ProteinsLentivirusNerve Growth FactorsNerve Tissue ProteinsNestinNeuronsRatsRats, Inbred F344Rats, Sprague-DawleySpinal Cord InjuriesStem Cell TransplantationStem CellsTransduction, GeneticTubulinConceptsNeural progenitor cellsSpinal cordNeurotrophic factorPositive cellsGFP-positive cellsContused spinal cordProgenitor cellsSpinal cord lesionsCortical neural progenitor cellsLong-term transgene expressionLentiviral vectorsRat spinal cordLentiviral vector-mediated transductionCord lesionsGreen fluorescent proteinReplacement therapyCell replacement therapyVector-mediated transductionNPC survivalLesion siteAstrocytic phenotypeImmune rejectionCordNeurological disordersNon-transduced cells