2019
Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation
Shubin A, Kollar B, Dillon S, Pomahac B, Libermann T, Riella L. Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation. Scientific Data 2019, 6: 314. PMID: 31819064, PMCID: PMC6901551, DOI: 10.1038/s41597-019-0324-y.Peer-Reviewed Original ResearchConceptsDevastating facial injuriesSevere rejection episodesAcute transplant rejectionType of transplantationPeripheral blood serumSOMAscan proteomics platformSatisfactory treatment optionAcute rejectionRejection episodesTransplant statusTransplantation centersTransplant rejectionTreatment optionsBiomarker discoverySkin biopsiesClinical dataHigh riskFacial injuriesInvasive biomarkersTransplantationAptamer-based technologiesFace transplantationPatientsBlood serumSerum proteins
2018
The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture
Diehm Y, Hirche C, Berger M, Heil J, Golatta M, Kotsougiani D, Pomahac B, Kneser U, Fischer S. The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture. Aesthetic Plastic Surgery 2018, 43: 836-844. PMID: 30456640, DOI: 10.1007/s00266-018-1267-y.Peer-Reviewed Original ResearchConceptsBacterium Clostridium histolyticumCapsular fibrosisHematoma formationTreatment optionsImplant pocketClostridium histolyticumSilicone implantsMiniature silicone implantsNovel treatment optionsPotential treatment optionInjection of collagenaseVessel wall architectureMethodsThirty-six ratsVessel wall thicknessCollagenase injectionSignificant complicationsBreast reconstructionCapsular contractureClinical safetyBreast cancerDay 1Application of collagenaseDay 120Implant sitesThin capsuleIncreased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, Dillon S, Gu X, Wyrobnik I, Murphy G, Pomahac B, Libermann T, Riella L. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Scientific Reports 2018, 8: 14915. PMID: 30297859, PMCID: PMC6175842, DOI: 10.1038/s41598-018-33272-7.Peer-Reviewed Original ResearchConceptsSevere rejectionFace transplantationLarge independent patient cohortsAcute rejection episodesAnti-rejection treatmentFirst postoperative yearLongitudinal serum samplesNon-invasive candidate biomarkersViable treatment optionSOMAscan proteomics platformIndependent patient cohortsFace transplant recipientsRejection episodesPostoperative yearTransplant recipientsDevastating injuriesMMP3 levelsTransplant rejectionHistological gradePatient cohortTreatment optionsSurrogate markerMMP3 proteinCandidate biomarkersTransplantation
2017
Role of Facial Vascularized Composite Allotransplantation in Burn Patients
Bharadia D, Sinha I, Pomahac B. Role of Facial Vascularized Composite Allotransplantation in Burn Patients. Clinics In Plastic Surgery 2017, 44: 857-864. PMID: 28888310, DOI: 10.1016/j.cps.2017.05.017.Peer-Reviewed Original ResearchConceptsComposite allotransplantationFacial Vascularized Composite AllotransplantationExtensive burn injuriesRisk of rejectionVascularized Composite AllotransplantationQuality of lifeLifelong regimenVCA patientsImmunosuppression medicationsPowerful reconstructive toolsBurn patientsTreatment optionsSurgical techniqueBurn injuryReconstructive surgeryPatientsReconstructive toolFace transplantationAllotransplantationImproved qualityFacial formImmunosuppressionMedicationsRegimenSurgery
2016
Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants
Fischer S, Diehm Y, Henzler T, Berger M, Kolbenschlag J, Latz A, Bueno E, Hirche C, Kneser U, Pomahac B. Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants. Aesthetic Plastic Surgery 2016, 41: 211-220. PMID: 28008464, DOI: 10.1007/s00266-016-0724-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantationBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisHumansImmunohistochemistryImplant Capsular ContractureInjections, IntralesionalMagnetic Resonance ImagingMicrobial CollagenasePregnancyRandom AllocationRatsRats, Inbred LewReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeUltrasonography, DopplerConceptsMagnetic resonance imagingBacterium Clostridium histolyticumSilicone implantsCapsular fibrosisCollagenase injectionTreatment groupsSkin perforationFrequent long-term complicationMethodsForty-eight ratsMiniature silicone implantsLong-term complicationsClostridium histolyticumViable treatment optionLevel of evidenceHigh-resolution ultrasoundCapsule thicknessInjection of collagenaseExpression levelsDays post injectionLevel AssignedThis journalLong-term effectivenessBackgroundCapsular contractureAnti-fibrotic genesTreatment optionsImplant pocketEfficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4
2013
Vascularized composite tissue allotransplantation – state of the art
Diaz‐Siso J, Bueno E, Sisk G, Marty F, Pomahac B, Tullius S. Vascularized composite tissue allotransplantation – state of the art. Clinical Transplantation 2013, 27: 330-337. PMID: 23581799, PMCID: PMC3724233, DOI: 10.1111/ctr.12117.Peer-Reviewed Original ResearchConceptsImmunosuppression-related side effectsVascularized composite tissue allotransplantationLong-term graft lossEarly post-operative periodChronic graft deteriorationPost-operative periodLong-term outcomesViable treatment optionConventional reconstructive techniquesComposite tissue allotransplantationAcute rejectionGraft lossGraft deteriorationTolerance inductionTreatment optionsLifelong immunosuppressionLower extremitiesImmune responseAnatomic locationReconstructive techniquesAbdominal wallSide effectsTissue allotransplantationFunctional restorationCellular therapy
2011
Restoration of Facial Form and Function After Severe Disfigurement from Burn Injury by a Composite Facial Allograft
Pomahac B, Pribaz J, Eriksson E, Annino D, Caterson S, Sampson C, Chun Y, Orgill D, Nowinski D, Tullius S. Restoration of Facial Form and Function After Severe Disfigurement from Burn Injury by a Composite Facial Allograft. American Journal Of Transplantation 2011, 11: 386-393. PMID: 21214855, DOI: 10.1111/j.1600-6143.2010.03368.x.Peer-Reviewed Original ResearchConceptsSevere disfigurementMedical historyBurn injuryFacial allograftAcute rejection episodesInitial clinical outcomesElectrical burn injuryFacial allotransplantationSevere facial disfigurementDonor's medical historyAntirejection treatmentRejection episodesPostoperative monthSurgical complicationsClinical outcomesNasal breathingTreatment optionsBolus treatmentPathological analysisMinimal doseNormal social lifeEsthetic resultsSignificant restorationFacial formFacial redness