2020
Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage
Okita Y, Koi M, Takeda K, Ross R, Mukherjee B, Koeppe E, Stoffel E, Galanko J, McCoy A, Keku T, Okugawa Y, Kitajima T, Toiyama Y, Martens E, Carethers J. Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage. Gut Pathogens 2020, 12: 46. PMID: 33005238, PMCID: PMC7526104, DOI: 10.1186/s13099-020-00384-3.Peer-Reviewed Original ResearchMicrosatellite instability-highCpG island hypermethylation phenotypeColorectal cancerMicrosatellite alterationsFusobacterium nucleatum infectionInflammatory tumor microenvironmentSubtypes of colorectal cancerDNA double strand breaksColorectal cancer cohortMicrosatellite instability-lowTumor microenvironmentFn infectionColorectal cancer tissuesHypermethylation phenotypeElevated levelsInfected cellsCancerInfectionAlterationsDouble strand breaksAssociated with microsatellite instability-highStrand breaks
2009
Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer
Vilar Sanchez E, Chow A, Raskin L, Iniesta M, Mukherjee B, Gruber S. Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer. Journal Of Clinical Oncology 2009, 27: 11028-11028. DOI: 10.1200/jco.2009.27.15_suppl.11028.Peer-Reviewed Original ResearchMSI cell linesDouble strand breaksMSS cell linesPARP inhibitor ABT-888ABT-888Cell linesInhibitor ABT-888Genetic instabilityDouble strand break repair pathwaysColorectal cancerMutation statusDouble strand break repairPARP inhibitorsMicrosatellite instable colorectal cancerSystems biology studiesSystems biology toolsMicrosatellite instabilitySensitivity to PARP inhibitionPreclinical activityStrand breaksMicrosatellite instability colorectal tumorsRepetitive sequencesColorectal cancer cell linesRAD50 geneMutator phenotype