Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer
Vilar Sanchez E, Chow A, Raskin L, Iniesta M, Mukherjee B, Gruber S. Preclinical testing of the PARP inhibitor ABT-888 in microsatellite instable colorectal cancer. Journal Of Clinical Oncology 2009, 27: 11028-11028. DOI: 10.1200/jco.2009.27.15_suppl.11028.Peer-Reviewed Original ResearchMSI cell linesDouble strand breaksMSS cell linesPARP inhibitor ABT-888ABT-888Cell linesInhibitor ABT-888Genetic instabilityDouble strand break repair pathwaysColorectal cancerMutation statusDouble strand break repairPARP inhibitorsMicrosatellite instable colorectal cancerSystems biology studiesSystems biology toolsMicrosatellite instabilitySensitivity to PARP inhibitionPreclinical activityStrand breaksMicrosatellite instability colorectal tumorsRepetitive sequencesColorectal cancer cell linesRAD50 geneMutator phenotype