Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage
Okita Y, Koi M, Takeda K, Ross R, Mukherjee B, Koeppe E, Stoffel E, Galanko J, McCoy A, Keku T, Okugawa Y, Kitajima T, Toiyama Y, Martens E, Carethers J. Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage. Gut Pathogens 2020, 12: 46. PMID: 33005238, PMCID: PMC7526104, DOI: 10.1186/s13099-020-00384-3.Peer-Reviewed Original ResearchMicrosatellite instability-highCpG island hypermethylation phenotypeColorectal cancerMicrosatellite alterationsFusobacterium nucleatum infectionInflammatory tumor microenvironmentSubtypes of colorectal cancerDNA double strand breaksColorectal cancer cohortMicrosatellite instability-lowTumor microenvironmentFn infectionColorectal cancer tissuesHypermethylation phenotypeElevated levelsInfected cellsCancerInfectionAlterationsDouble strand breaksAssociated with microsatellite instability-highStrand breaks