2024
Decoding the molecular script of 2′-O-ribomethylation: Implications across CNS disorders
Verma A, Roy B, Dwivedi Y. Decoding the molecular script of 2′-O-ribomethylation: Implications across CNS disorders. Heliyon 2024, 10: e39036. PMCID: PMC11550049, DOI: 10.1016/j.heliyon.2024.e39036.Peer-Reviewed Original ResearchRibosomal RNARibosome functionRibosomal RNA structuresPeptidyl transferase centerPost-transcriptional modificationsDefective ribosome biogenesisRibosome biogenesisRibosome integrityRNA modificationsRegulatory networksTranslational efficiencyDecoding siteImpaired mRNA translationMRNA translationBase modificationsPathophysiology of CNS disordersCNS disordersRNA integrityProtein synthesisRibosomal dysfunctionRNANeurodegenerative diseasesDisease pathologySpectrum of CNS disordersPrecision medicine
2023
The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties
Jiang R, Roy B, Wu Q, Mohanty S, Nowak R, Shaw A, Kleinstein S, O’Connor K. The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties. ImmunoHorizons 2023, 7: 310-322. PMID: 37171806, PMCID: PMC10579972, DOI: 10.4049/immunohorizons.2200078.Peer-Reviewed Original ResearchConceptsInclusion body myositisMemory B cellsCell infiltrateBody myositisB cellsIBM muscle biopsiesB-cell infiltratesPlasma cell infiltrateClass-switched IgGMuscle tissueAdaptive immune receptor repertoire sequencingHumoral responseHealthy controlsIgA isotypePlasma cellsCell repertoireMuscle biopsyInfiltratesDegenerative disordersDisease pathologyRepertoire sequencingSkeletal muscleDermatomyositisPolymyositisMyositis