Featured Publications
Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? — A scoping review
Nowroozpoor A, Gutterman D, Safdar B. Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? — A scoping review. Microvascular Research 2020, 134: 104123. PMID: 33333140, DOI: 10.1016/j.mvr.2020.104123.Peer-Reviewed Original ResearchConceptsMicrovascular dysfunctionUnderlying systemic processC-reactive proteinLow-density cholesterolMulti-system involvementUric acidDifferent disease entitiesMulti-system manifestationsVon Willebrand factorNT-proBNPEndothelial dysfunctionTotal cholesterolClinical evidenceImmune activationSystemic disordersVitamin DIL-6Asymmetric dimethylarginineBlood biomarkersInforms cliniciansDisease entityCystatin CVital organsDysfunctionCommon biomarkersDiagnosis of coronary microvascular dysfunction in the clinic
Ong P, Safdar B, Seitz A, Hubert A, Beltrame J, Prescott E. Diagnosis of coronary microvascular dysfunction in the clinic. Cardiovascular Research 2020, 116: 841-855. PMID: 31904824, DOI: 10.1093/cvr/cvz339.Peer-Reviewed Original ResearchConceptsInterventional diagnostic proceduresCoronary microvascular dysfunctionCoronary microcirculationMicrovascular dysfunctionIntracoronary acetylcholine testingCoronary microvascular functionCoronary blood flowIndividual patient characteristicsChronic pathologic conditionsAcetylcholine testingCoronary spasmRecurrent symptomsCoronary vasoconstrictorPatient characteristicsCoronary thrombosisMicrovascular functionInvasive assessmentClinical conditionsEffective treatmentRespective patientsBlood flowCardiac metabolismClinical importancePathologic conditionsInvasive method
2022
Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience)
Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.Peer-Reviewed Original ResearchConceptsSpontaneous coronary artery dissectionPatient Health Questionnaire-9Coronary artery dissectionPSS-14 scoreArtery dissectionBaseline PHQ-9 scoreAcute myocardial infarction patientsCardiovascular risk factorsPHQ-9 scoresAcute myocardial infarctionMyocardial infarction patientsYears of agePerceived Stress Scale scoresStress Scale scoresLinear mixed-effects analysisSCAD casesVIRGO StudyQuestionnaire-9Infarction patientsMixed-effects analysisMyocardial infarctionSubgroup analysisRisk factorsRoutine screeningClinical acuityHealth status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience
Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Khera R, Lu Y, Spatz ES, Ng VG, Gupta A, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience. PLOS ONE 2022, 17: e0265624. PMID: 35320296, PMCID: PMC8942215, DOI: 10.1371/journal.pone.0265624.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Vessel AnomaliesCoronary VesselsFemaleHealth StatusHumansMiddle AgedMyocardial InfarctionQuality of LifeVascular DiseasesConceptsSpontaneous coronary artery dissectionAcute myocardial infarctionAMI patientsCoronary artery dissectionYoung AMI patientsHealth status outcomesHealth status instrumentsSCAD patientsArtery dissectionMyocardial infarctionStatus outcomesPatientsOutcomesHousehold incomeCollege educationInfarction