2023
Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): design of a multicentre, randomised, double-blind, placebo-controlled, parallel-group study
Rafique Z, Budden J, Quinn C, Duanmu Y, Safdar B, Bischof J, Driver B, Herzog C, Weir M, Singer A, Boone S, Soto-Ruiz K, Peacock W. Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): design of a multicentre, randomised, double-blind, placebo-controlled, parallel-group study. BMJ Open 2023, 13: e071311. PMID: 37308268, PMCID: PMC10277034, DOI: 10.1136/bmjopen-2022-071311.Peer-Reviewed Original ResearchConceptsNet clinical benefitInstitutional review boardProportion of participantsAdjunct treatmentClinical benefitMean changePlacebo-controlled studyParallel-group studySingle oral doseEmergency department managementLocal institutional review boardCentral institutional review boardSeverity of changesPrimary endpointSafety endpointSecondary endpointsAdverse eventsSerum potassiumOral doseSecond doseSerum KStudy completionTreatment protocolAdditional interventionsCommon treatment
2014
Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients
Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D’onofrio G. Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2014, 13: 14-19. PMID: 24526146, DOI: 10.1097/hpc.0000000000000001.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsCPU patientsNormal troponinAdverse eventsCardiac eventsMultiple logistic regression modelComposite adverse eventsElevated creatinine kinaseObservation unit patientsSerial troponin testingStandardized chart reviewRetrospective cohort studyAcute coronary syndromeNational Death RegistryCoronary artery diseaseLogistic regression modelsPositive troponinPrior CADRenal insufficientCoronary syndromeHemodynamic instabilityChart reviewCohort studyDeath RegistryIschemic electrocardiogram