2023
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke
Lyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, Kim S, Cabeen R, Koenig J, Akhter K, Arbab A, Avery B, Beatty H, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman A, Hyder F, Imai T, Johnson C, Khan M, Kamat P, Karuppagounder S, Kumskova M, Mihailovic J, Mandeville J, Morais A, Patel R, Sanganahalli B, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez S, Aronowski J, Ayata C, Chauhan A, Leira E, Hess D, Koehler R, McCullough L, Sansing L. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Science Translational Medicine 2023, 15: eadg8656. PMID: 37729432, DOI: 10.1126/scitranslmed.adg8656.Peer-Reviewed Original ResearchConceptsPreclinical assessmentFocal cerebral ischemic insultAcute ischemic strokeCerebral ischemic insultLarge clinical trialsDiet-induced obesityNew clinical interventionsIntravascular thrombectomyIschemic strokeStroke treatmentHypertensive ratsIschemic insultBlinded assessmentClinical trialsYoung miceTreatment candidatesExclusion criteriaAnimal modelsYoung ratsFutile interventionsPreclinical trialsClinical interventionsFutility boundariesMiceDisease areas
2022
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results
Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A, Siddiqui S, Sheth K, Matouk C, Cruz C, Zhou J, Dawson V, Dawson T, Liang J, van Zijl P, Zeiler S, Taylor Kimberly W, Erdogan T, Yu L, Mandeville J, Whittier J. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke 2022, 53: 1802-1812. PMID: 35354299, PMCID: PMC9038686, DOI: 10.1161/strokeaha.121.038047.Peer-Reviewed Original ResearchConceptsPreclinical assessmentStroke treatmentCandidate treatmentMiddle cerebral artery occlusion (MCAO) surgeryClinical stroke trialsSuccessful stroke treatmentInclusion/exclusion criteriaStroke clinical trialsClinical trial designYoung male animalsComorbid diseasesOcclusion surgeryCerebral ischemiaNeurological disabilityComorbid conditionsStroke trialsProtocol adherenceBlinded assessmentSuch therapyClinical trialsClinical studiesExclusion criteriaTrial designAged animalsOutcome assessment
2020
Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence
Parent M, Chitturi J, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence. Journal Of Neurotrauma 2020, 37: 966-974. PMID: 31830867, PMCID: PMC7175625, DOI: 10.1089/neu.2019.6486.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryKaempferol treatmentDiffusion tensor imagingFractional anisotropyBrain injuryParenchymal microstructureCallosal fractional anisotropyInterhemispheric structural connectivityH post-TBINeural connectivitySelect brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingTBI prognosisCerebrovascular reactivityFunctional outcomeImaging outcomesNeurovascular couplingPost-TBITBI outcomesTBI pathophysiologyMetabolic benefitsResting-state functional connectivity networksRsFC changesWhole brain
2018
Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development
Parent M, Li Y, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development. Journal Of Neurotrauma 2018, 36: 601-608. PMID: 29855211, PMCID: PMC6354598, DOI: 10.1089/neu.2018.5741.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDevelopmental traumatic brain injuryResting-state functional connectivityDiffusion tensor imagingCerebrovascular resistanceIpsilateral hippocampusBrain injuryLateral fluid percussion traumatic brain injuryFluid percussion traumatic brain injuryNeuronal connectivityFunctional MRIModerate traumatic brain injuryParenchymal microstructureInterhemispheric structural connectivityFluid percussion injuryCortical blood flowNeural connectivityMicrostructural integrityInterhemispheric asymmetryIpsilateral thalamusNeurovascular functionCerebrovascular reactivityMotor cortexRSFC strengthSubcortical alterationsSpontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb
Thompson GJ, Sanganahalli BG, Baker KL, Herman P, Shepherd GM, Verhagen JV, Hyder F. Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb. NeuroImage 2018, 172: 586-596. PMID: 29374582, PMCID: PMC5910178, DOI: 10.1016/j.neuroimage.2018.01.051.Peer-Reviewed Original Research
2016
Metabolic demands of neural-hemodynamic associated and disassociated areas in brain
Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F. Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. Cerebrovascular And Brain Metabolism Reviews 2016, 36: 1695-1707. PMID: 27562867, PMCID: PMC5076793, DOI: 10.1177/0271678x16664531.Peer-Reviewed Original ResearchConceptsVentral posterolateral thalamic nucleusFunctional magnetic resonance imagingMulti-unit activityLocal field potentialsMetabolic demandsPosterolateral thalamic nucleusBlood oxygenation level-dependent (BOLD) responseSensory-evoked responsesCortical local field potentialsThalamic local field potentialsMagnetic resonance imagingLevel-dependent responsesSimilar metabolic demandThalamic nucleiForelimb cortexBlood flowBlood volumeCBV responseResonance imagingLatency differenceHemodynamicsBOLD signalOxidative metabolismDifferent metabolic demandsField potentialsHypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model
Kaneko G, Sanganahalli BG, Groman SM, Wang H, Coman D, Rao J, Herman P, Jiang L, Rich K, de Graaf RA, Taylor JR, Hyder F. Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biological Psychiatry 2016, 81: 503-513. PMID: 27450031, PMCID: PMC5130616, DOI: 10.1016/j.biopsych.2016.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBiomarkersBrainDecision MakingDiffusion Tensor ImagingDisease Models, AnimalFemaleMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMethylazoxymethanol AcetateMultimodal ImagingPrefrontal CortexRatsRats, Sprague-DawleyReversal LearningRewardSchizophreniaSchizophrenic PsychologyConceptsMAM ratsEarly schizophreniaReversal-learning taskEarly behavioral markersResting-state functional magnetic resonanceFunctional magnetic resonanceMethylazoxymethanol acetate (MAM) rat modelFunctional brain biomarkersPerceptual problemsBehavioral markersOrbitofrontal cortexLate adolescenceFunctional connectivityRat modelEarly diagnosisThree-choiceBehavioral studiesBehavioral symptomsPosterior corpus callosumSubstance abuseProdromal patientsSubthreshold symptomsVisual cortexBrain biomarkersSaline-treated controls
2015
Brain region and activity-dependent properties of M for calibrated fMRI
Shu CY, Herman P, Coman D, Sanganahalli BG, Wang H, Juchem C, Rothman DL, de Graaf RA, Hyder F. Brain region and activity-dependent properties of M for calibrated fMRI. NeuroImage 2015, 125: 848-856. PMID: 26529646, PMCID: PMC4691415, DOI: 10.1016/j.neuroimage.2015.10.083.Peer-Reviewed Original ResearchRole of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks
Kannurpatti SS, Sanganahalli BG, Herman P, Hyder F. Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks. NMR In Biomedicine 2015, 28: 1579-1588. PMID: 26439799, PMCID: PMC4621005, DOI: 10.1002/nbm.3421.Peer-Reviewed Original ResearchConceptsSimilar dose-dependent decreaseDose-dependent decreaseCaudate putamenBrain regionsBlood oxygen level-dependent fluctuationsBrain energy metabolismLevel-dependent fluctuationsBrain functional organizationSomatosensory cortexAnesthetized ratsDifferent functional networksFunctional organizationDrug treatmentVascular densityHippocampal regionThalamic regionsDifferent physiological impactsBOLD fluctuationsRSFC networksIntrinsic activityState fMRINeural signalingBrain networksPutamenFMRI brain networksDistribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure
Coman D, Sanganahalli BG, Jiang L, Hyder F, Behar KL. Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure. NMR In Biomedicine 2015, 28: 1257-1266. PMID: 26286889, PMCID: PMC4573923, DOI: 10.1002/nbm.3375.Peer-Reviewed Original ResearchConceptsNeurovascular couplingBlood flowNeuronal activityNeural activityWhole-body hyperthermiaAbused psychostimulantMethylenedioxymethamphetamine (MDMA) exposureNeurovascular responseCortex temperatureMDMA effectsRat cortexRat brainBrain temperatureSubcortical regionsBrain regionsCortexSubcortexMDMA actionSkeletal muscleMonoaminergic stimulationBrainMDMACBFBody temperatureThermogenesisDistributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal Epilepsy
Song Y, Sanganahalli BG, Hyder F, Lin WC, Riera JJ. Distributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal Epilepsy. PLOS ONE 2015, 10: e0134352. PMID: 26226628, PMCID: PMC4520590, DOI: 10.1371/journal.pone.0134352.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesResting-state networksFocal epilepsyIrritative zoneBOLD responseType of epilepsyConnected brain areasLevel-dependent responsesDefault mode networkFocal epileptogenesisChronic modelBOLD deactivationEpileptiform dischargesBrain areasAltered spatial patternSubcortical structuresEpilepsyMode networkEEG recordingsAlterationsDifferent brain modulesConnectivity patternsIndividual alterationsBrain modulesDifferent manifestations
2014
DYNAmic Multi‐coIl TEchnique (DYNAMITE) shimming of the rat brain at 11.7 T
Juchem C, Herman P, Sanganahalli BG, Brown PB, McIntyre S, Nixon TW, Green D, Hyder F, Graaf R. DYNAmic Multi‐coIl TEchnique (DYNAMITE) shimming of the rat brain at 11.7 T. NMR In Biomedicine 2014, 27: 897-906. PMID: 24839167, PMCID: PMC4120278, DOI: 10.1002/nbm.3133.Peer-Reviewed Original ResearchDecreased Resting Functional Connectivity after Traumatic Brain Injury in the Rat
Mishra AM, Bai X, Sanganahalli BG, Waxman SG, Shatillo O, Grohn O, Hyder F, Pitkänen A, Blumenfeld H. Decreased Resting Functional Connectivity after Traumatic Brain Injury in the Rat. PLOS ONE 2014, 9: e95280. PMID: 24748279, PMCID: PMC3991600, DOI: 10.1371/journal.pone.0095280.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryContralateral parietal cortexSham-operated animalsFunctional magnetic resonance imagingParietal cortexFunctional connectivityFunctional imagingBrain injuryAdult male Sprague-Dawley ratsLateral fluid percussion injuryExperimental traumatic brain injuryMale Sprague-Dawley ratsFluid percussion injuryPost-traumatic epileptogenesisSeizure-susceptibility testState BOLD-fMRISide of injuryAbnormal functional connectivitySham-operated ratsSprague-Dawley ratsMagnetic resonance imagingSeizure susceptibilitySkull electrodesEpileptiform dischargesFunctional imaging data
2013
Functional MRI and neural responses in a rat model of Alzheimer's disease
Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage 2013, 79: 404-411. PMID: 23648961, PMCID: PMC3700380, DOI: 10.1016/j.neuroimage.2013.04.099.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional magnetic resonance imagingCerebral cortexAD brainSomatosensory cortexRat modelCortical functionNeural responsesAge-matched healthy controlsAD rat modelContralateral somatosensory cortexSensory-evoked responsesHigh-field functional magnetic resonance imagingBrain functional responsesMagnetic resonance imagingAD ratsControl ratsHealthy controlsThalamic responsesNormal ratsCortical responsesAD modelSubcortical functionBrain plaquesElectrical stimulationMitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI. PLOS ONE 2013, 8: e63317. PMID: 23650561, PMCID: PMC3641133, DOI: 10.1371/journal.pone.0063317.Peer-Reviewed Original ResearchConceptsSpontaneous neuronal activityNeuronal activityCerebral blood flow fluctuationsFunctional connectivityRelevant translational modelState functional connectivityTraumatic brain injuryBlood flow fluctuationsIntrinsic brain activityBrain functional connectivityResting-state fMRIMitochondrial functional stateNeuronal electrical activityFunctional stateReduced RSFCNeural metabolismBrain injuryHemodynamic fluctuationsHemodynamic responseMCU inhibitionNeocortical activityBOLD fluctuationsTranslational modelState fMRIBOLD responseMitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 1115-1126. PMID: 23591650, PMCID: PMC3705442, DOI: 10.1038/jcbfm.2013.61.Peer-Reviewed Original ResearchConceptsSensory-evoked cortical activityCentral nervous system metabolismCerebral blood flowCortical neuronal activityStimulus-evoked responsesCentral nervous systemBlood oxygen level dependenceNeocortical excitabilityBrain signalingHemodynamic responseBlood flowNeuronal activityNervous systemCortical activityNeocortical activityCalcium changesExtracellular electrophysiologyMCU activityMCU inhibitorVivo impactVivo mitochondriaDependent mannerMultiple subcellular compartmentsRole of mitochondriaUniporter activityLactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain
2012
Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System
Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F. Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System. Cerebral Cortex 2012, 23: 210-222. PMID: 22298731, PMCID: PMC3513959, DOI: 10.1093/cercor/bhs008.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGeneral linear modelingSuperior colliculusBOLD responseBasal blood flowNeural activityRat visual systemBlood oxygenation level-dependent (BOLD) responsePrimary visual cortexMagnetic resonance imagingLevel-dependent responsesNeurovascular couplingRat brainBlood flowVisual cortexResonance imagingStimulation paradigmV1 signalsLight flashesOnset/Neural signalsResponseV1Visual systemColliculus
2011
Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain
Herman P, Sanganahalli BG, Hyder F, Eke A. Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain. NeuroImage 2011, 58: 1060-1069. PMID: 21777682, PMCID: PMC3705180, DOI: 10.1016/j.neuroimage.2011.06.082.Peer-Reviewed Original Research
2009
Cerebral oxygen demand for short‐lived and steady‐state events
Herman P, Sanganahalli BG, Blumenfeld H, Hyder F. Cerebral oxygen demand for short‐lived and steady‐state events. Journal Of Neurochemistry 2009, 109: 73-79. PMID: 19393011, PMCID: PMC2714475, DOI: 10.1111/j.1471-4159.2009.05844.x.Peer-Reviewed Original Research