2020
Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort.
Rasouli N, Younes N, Utzschneider KM, Inzucchi SE, Balasubramanyam A, Cherrington AL, Ismail-Beigi F, Cohen RM, Olson DE, DeFronzo RA, Herman WH, Lachin JM, Kahn SE, Crandall J, McKee M, Brown-Friday J, Xhori E, Ballentine-Cargill K, Duran S, Lukin J, Beringher S, de la torre S, Phillips L, Burgess E, Olson D, Rhee M, Wilson P, Raines T, Costello J, Gullett C, Maher-Albertelli M, Morehead F, Mungara R, Person S, Savoye L, Sibymon M, Tanukonda S, Ann White C, Holloway L, Adams C, Ross A, Balasubramanyam A, Gonzalez E, Wright C, Hollander P, Roe E, Uy A, Burt P, Estrada L, Chionh K, Ismail-Beigi F, Falck-Ytter C, Kassem L, Sood A, Tiktin M, Cramer B, Iacoboni J, Kononets M, Kulow T, Newman C, Stancil K, Sanders C, Tucker L, Werner A, Krol A, McPhee G, Patel C, Colosimo L, Goland R, Pring J, Kringas P, Tejada J, Hausheer C, Schneier H, Gumpel K, Kirpitch A, Green J, AbouAssi H, Chatterjee R, Feinglos M, Jones J, Khan S, Kimpel J, Zimmer R, Furst M, Satterwhite B, Thacker C, Kreider K, Mather K, Lteif A, Hamilton T, Patel N, Riera G, Jackson M, Pirics V, Howard D, Aguillar D, Hurt S, Bergenstal R, Carlson A, Martens T, Johnson M, Hill R, Hyatt J, Jensen C, Madden M, Martin D, Willis H, Konerza W, Passi R, Kleeberger K, Fortmann S, Herson M, Mularski K, Glauber H, Prihoda J, Ash B, Carlson C, Ramey P, Schield E, Torgrimson-Ojerio B, Arnold K, Kauffman B, Panos E, Sahnow S, Bays K, Cook J, Gluth J, Sasaki D, Schell K, Criscola J, Friason C, Jones S, Nazarov S, Barzilay J, Rassouli N, Puttnam R, Curtis M, Stokes K, Hollis B, Sanders-Jones C, Nelson R, El-Haqq Z, Kolli A, Tran T, Wexler D, Larkin M, Meigs J, Dushkin A, Rocchio G, Chambers B, Yepes M, Steiner B, Dulin H, Cayford M, DeManbey A, Gurry L, Hillard M, Martin K, Stevens C, Thangthaeng N, Kochis R, Raymond E, Ripley V, Park J, Aroda V, Ghazi A, Loveland A, Hurtado M, Kuhn A, Mofor F, Florez H, Valencia W, Marks J, Oropesa-Gonzalez L, Riccio Veliz A, Nieto-Martinez R, Gutt M, Ahmann A, Aby-Daniel D, Joarder F, Morimoto V, Sprague C, Yamashita D, Cady N, Kirchhoff P, Rivera-Eschright N, Adducci J, Gomez B, Goncharova A, Hox S, Petrovitch H, Matwichyna M, Jenkins V, Bermudez N, Ishii R, Hsia D, Cefalu W, Greenway F, Waguespack C, King E, Haynes N, Thomassie A, Bourgeois B, Hazlett C, Henry R, Mudaliar S, Boeder S, Pettus J, Diaz E, DeLue C, Castro E, Hernandez S, Krakoff J, Curtis J, Killean T, Joshevama E, Diaz E, Martin D, Karshner T, Albu J, Pi-Sunyer F, Frances S, Maggio C, Ellis E, Bastawrose J, Gong X, Banerji M, August P, Lorber D, Brown N, Josephson D, Thomas L, Tsovian M, Cherian A, Jacobson M, Mishko M, Kirkman M, Bergamo K, Buse J, Dostou J, Young L, Goley A, Kerr J, Largay J, Guarda S, Cuffee J, Culmer D, Fraser R, Almeida H, Coffer S, Debnam E, Kiker L, Morton S, Garvey K, Fuller G, Garvey W, Cherrington A, Golson D, Griffith O, Catherine M, Agne A, McCullars S, Cohen R, Craig J, Kersey K, Rogge M, Wilson C, Burton K, Lipp S, Mary Beth V, Rasouli N, Schroeder E, Steiner S, Baker C, Underkofler C, Douglass S, Sivitz W, Cline E, Knosp L, McConnell J, Lowe T, Herman W, Pop-Busui R, Tan M, Martin C, Waltje A, Goodhall L, Eggleston R, Kuo S, Bule S, Kessler N, LaSalle E, Seaquist E, Bantle A, Kumar A, Redmon B, Bantle J, Harindhanavudhi T, Coe M, Mech M, Taddese A, Lesne L, Smitha S, Desouz C, Kuechenmeister L, Shivaswamy V, Morales A, Rodriguez M, Seipel K, Alfred A, Eggert J, Lord G, Taylor W, Tillson R, Schade D, Adolphe A, Burge M, Duran-Valdez E, Martinez J, Hernandez McGinnis D, Pucchetti B, Scripsick E, DeFronzo R, Cersosimo E, Abdul-Ghani M, Triplitt C, Verastiqui H, Garza R, Wright K, Puckett C, Raskin P, Rhee C, Abraham S, Jordan L, Sao S, Morton L, Smith O, Osornio Walker L, Schnurr-Breen L, Ayala R, Kraymer R, Sturgess D, Utzschneider K, Kahn S, Alarcon-Casas Wright L, Boyko E, Tsai E, Trence D, Fattaleh B, Montgomery B, Atkinson K, Concepcion T, Kozedub A, Moak C, Rhothisen S, Elasy T, Martin S, Shackelford L, Goidel R, Hinkle N, Lipps Hogan J, Lovell C, Myers J, McGill J, Salam M, Kissel S, Schweiger T, Recklein C, Tamborlane W, Gatcomb P, Camp A, Gulanski B, Inzucchi S, Pham K, Alguard M, Lessard K, Perez M, Magenheimer E, Montoza A, Nathan D, Nathan D, Lachin J, Buse J, Kahn S, Krause-Steinrauf H, Larkin M, Tiktin M, Wexler D, Burch H, Linder B, Bremer A, Lachin J, Krause-Steinrauf H, Younes N, Backman M, Bebu I, Buys C, Fagan Murphy A, Gao Y, Gramzinski M, Hall S, Legowski E, Arey A, Bethepu J, Lund C, Mangat Dhaliwal P, McGee P, Mesimer E, Ngo L, Steffes M, Seegmiller J, Saenger A, Arends V, Gabrielson D, Conner T, Warren S, Day J, Scrymgeour A, Soliman E, Zhang Z, Campbell C, Hu J, Keasler L, Hensley S, Li Y, Herman W, Martin C, Waltje A, Kuo S, Mihalcea R, Perez-Rosas V, Prosser L, Resnicow K, Ye W, Shao H, Zhang P, Luchsinger J, Sanchez D, Burch H, Bremer A, Linder B, Fradkin J, Groessl E, Chong H, Hillery N, Abdouch I, Brantley P, Broyles F, Canaris G, Copeland P, Craine J, Fein W, Lee M, Meiners R, Meiners V, O’Neal H, Park J, Sledge E, Steppel-Resnick J, Turchin A, Brooks-Worrell B, Hampe C, Newgard C, Palmer J, Shojaie A, Higgins J, Fischer L, Golden S, Gonzalez J, Naik A, Walker E, Doner Lotenberg L, Gallivan J, Lim J, Tuncer D, Behringer-Massera S. Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort. Diabetes Care 2020, 44: 340-349. PMID: 33334808, PMCID: PMC7818323, DOI: 10.2337/dc20-1787.Peer-Reviewed Original ResearchConceptsΒ-cell functionTG/HDLBlack/African AmericanAmerican Indians/Alaska NativesDisposition indexInsulin sensitivityHigher HbAOral glucose tolerance testAfrican AmericansGlycemia Reduction ApproachesHigher disposition indexHDL cholesterol ratioAlaska NativesGlucose tolerance testOral disposition indexC-peptide indexSimilar insulin sensitivityType 2 diabetesYears of ageCross-sectional analysisBMI 34.2Metformin monotherapyBaseline characteristicsInsulinogenic indexLower HbAOptimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight
Sivitz W, Phillips L, Wexler D, Fortmann S, Camp A, Tiktin M, Perez M, Craig J, Hollander P, Cherrington A, Aroda V, Tan M, Krakoff J, Rasouli N, Butera N, Younes N, Crandall J, Diane McKee M, Brown-Friday J, Xhori E, Ballentine-Cargill K, Duran S, Lukin J, Beringher S, Gonzalez de la torre S, Phillips L, Burgess E, Olson D, Rhee M, Wilson P, Stephanie Raines T, Costello J, Gullett C, Maher-Albertelli M, Morehead F, Mungara R, Person S, Savoye L, Sibymon M, Tanukonda S, Ann White C, Holloway L, Adams C, Ross A, Balasubramanyam A, Gonzalez E, Wright C, Hollander P, Roe E, Uy A, Burt P, Estrada L, Chionh K, Ismail-Beigi F, Falck-Ytter C, Sayyed Kassem L, Sood A, Tiktin M, Cramer B, Iacoboni J, Kononets M, Kulow T, Newman C, Stancil K, Sanders C, Tucker L, Werner A, Krol A, McPhee G, Patel C, Colosimo L, Goland R, Pring J, Kringas P, Tejada J, Hausheer C, Schneier H, Gumpel K, Kirpitch A, Green J, AbouAssi H, Chatterjee R, Feinglos M, English Jones J, Khan S, Kimpel J, Zimmer R, Furst M, Satterwhite B, Thacker C, Evans Kreider K, Mather K, Lteif A, Hamilton T, Patel N, Riera G, Jackson M, Pirics V, Howard D, Aguillar D, Hurt S, Bergenstal R, Carlson A, Martens T, Johnson M, Hill R, Hyatt J, Jensen C, Madden M, Martin D, Willis H, Konerza W, Passi R, Kleeberger K, Fortmann S, Herson M, Mularski K, Glauber H, Prihoda J, Ash B, Carlson C, Anne Ramey P, Schield E, Torgrimson-Ojerio B, Arnold K, Kauffman B, Panos E, Sahnow S, Bays K, Cook J, Gluth J, Sasaki D, Schell K, Criscola J, Friason C, Jones S, Nazarov S, Barzilay J, Rassouli N, Puttnam R, Curtis M, Stokes K, Hollis B, Sanders-Jones C, Nelson R, El-Haqq Z, Kolli A, Tran T, Wexler D, Mary L, Meigs J, Dushkin A, Rocchio G, Chambers B, Yepes M, Steiner B, Dulin H, Cayford M, DeManbey A, Gurry L, Hillard M, Martin K, Stevens C, Thangthaeng N, Kochis R, Raymond E, Ripley V, Park J, Aroda V, Ghazi A, Loveland A, Hurtado M, Kuhn A, Mofor F, Florez H, Valencia W, Marks J, Oropesa-Gonzalez L, Riccio Veliz A, Nieto-Martinez R, Gutt M, Ahmann A, Aby-Daniel D, Joarder F, Morimoto V, Sprague C, Yamashita D, Cady N, Kirchhoff P, Rivera-Eschright N, Adducci J, Gomez B, Goncharova A, Hox S, Petrovitch H, Matwichyna M, Jenkins V, Bermudez N, Ishii R, Hsia D, Cefalu W, Greenway F, Waguespack C, King E, Haynes N, Thomassie A, Bourgeois B, Hazlett C, Henry R, Mudaliar S, Boeder S, Pettus J, Diaz E, DeLue C, Castro E, Hernandez S, Krakoff J, Curtis J, Killean T, Joshevama E, Diaz E, Martin D, Karshner T, Albu J, Pi-Sunyer F, Frances S, Maggio C, Ellis E, Bastawrose J, Gong X, Ann Banerji M, August P, Lorber D, Brown N, Josephson D, Thomas L, Tsovian M, Cherian A, Jacobson M, Mishko M, Kirkman M, Bergamo K, Buse J, Dostou J, Young L, Goley A, Kerr J, Largay J, Guarda S, Cuffee J, Culmer D, Fraser R, Almeida H, Coffer S, Debnam E, Kiker L, Morton S, Josey K, Fuller G, Garvey W, Cherrington A, Golson D, Griffith O, Catherine Robertson M, Agne A, McCullars S, Cohen R, Craig J, Kersey K, Rogge M, Wilson C, Burton K, Lipp S, Vonder Meulen M, Rasouli N, Schroeder E, Steiner S, Baker C, Underkofler C, Douglass S, Sivitz W, Cline E, Knosp L, McConnell J, Lowe T, Herman W, Pop-Busui R, Tan M, Martin C, Waltje A, Goodhall L, Eggleston R, Kuo S, Bule S, Kessler N, LaSalle E, Seaquist E, Bantle A, Kumar A, Redmon B, Bantle J, Harindhanavudhi T, Coe M, Mech M, Taddese A, Lesne L, Smith S, Desouza C, Kuechenmeister L, Shivaswamy V, Laura Morales A, Rodriguez M, Seipel K, Alfred A, Eggert J, Lord G, Taylor W, Tillson R, Schade D, Adolphe A, Burge M, Duran-Valdez E, Martinez J, McGinnis D, Pucchetti B, Scripsick E, DeFronzo R, Cersosimo E, Abdul-Ghani M, Triplitt C, Verastiqui H, Irene Garza R, Wright K, Puckett C, Raskin P, Rhee C, Abraham S, Fan Jordan L, Sao S, Morton L, Smith O, Osornio Walker L, Schnurr-Breen L, Ayala R, Brian Kraymer R, Sturgess D, Utzschneider K, Kahn S, Alarcon-Casas Wright L, Boyko E, Tsai E, Trence D, Fattaleh B, Montgomery B, Atkinson K, Concepcion T, Kozedub A, Moak C, Rhothisen S, Elasy T, Martin S, Shackelford L, Goidel R, Hinkle N, Lipps Hogan J, Lovell C, Myers J, McGill J, Salam M, Kissel S, Schweiger T, Recklein C, Tamborlane W, Gatcomb P, Camp A, Gulanski B, Inzucchi S, Pham K, Alguard M, Lessard K, Perez M, Magenheimer E, Montoza A, Nathan D, Lachin J, Buse J, Kahn S, Krause-Steinrauf H, Larkin M, Tiktin M, Wexler D, Burch H, Linder B, Bremer A, Lachin J, Krause-Steinrauf H, Younes N, Backman M, Bebu I, Buys C, Fagan Murphy A, Gao Y, Gramzinski M, Hall S, Legowski E, Arey A, Bethepu J, Lund C, Mangat Dhaliwal P, McGee P, Mesimer E, Ngo L, Steffes M, Seegmiller J, Saenger A, Arends V, Gabrielson D, Conner T, Warren S, Day J, Scrymgeour A, Soliman E, Zhang Z, Campbell C, Hu J, Keasler L, Hensley S, Li Y, Herman W, Martin C, Waltje A, Kuo S, Mihalcea R, Perez-Rosas V, Prosser L, Resnicow K, Ye W, Shao H, Zhang P, Luchsinger J, Sanchez D, Burch H, Bremer A, Linder B, Fradkin J, Groessl E, Chong H, Hillery N, Abdouch I, Brantley P, Broyles F, Canaris G, Copeland P, Craine J, Fein W, Lee M, Meiners R, Meiners V, O’Neal H, Park J, Sledge E, Steppel-Resnick J, Turchin A, Brooks-Worrell B, Hampe C, Newgard C, Palmer J, Shojaie A, Higgins J, Fischer L, Golden S, Gonzalez J, Naik A, Walker E, Doner Lotenberg L, Gallivan J, Lim J, Tuncer D, Behringer-Massera S. Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight. Diabetes Care 2020, 43: 940-947. PMID: 32139384, PMCID: PMC7171946, DOI: 10.2337/dc19-1769.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood GlucoseBody WeightCalibrationComparative Effectiveness ResearchDiabetes Mellitus, Type 2Dose-Response Relationship, DrugDrug Therapy, CombinationFemaleGlycated HemoglobinHumansHypoglycemic AgentsInsulinLiraglutideMaleMaximum Tolerated DoseMetforminMiddle AgedSitagliptin PhosphateSulfonylurea CompoundsWeight LossConceptsType 2 diabetesLow doseBody weightGlycemia Reduction ApproachesGlucose-lowering drugsSuboptimal glycemic controlExercise counselingMetformin therapyPrespecified analysisGlycemic controlPrimary outcomeMedication adherenceHigher HbASD changeDiabetesMetforminGlycemiaDoseWeight lossHbAGreater reductionDaysParticipantsGrade cohorts
2013
Increased Brain Transport and Metabolism of Acetate in Hypoglycemia Unawareness
Gulanski BI, De Feyter HM, Page KA, Belfort-DeAguiar R, Mason GF, Rothman DL, Sherwin RS. Increased Brain Transport and Metabolism of Acetate in Hypoglycemia Unawareness. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 3811-3820. PMID: 23796565, PMCID: PMC4425818, DOI: 10.1210/jc.2013-1701.Peer-Reviewed Original ResearchConceptsHypoglycemia-associated autonomic failureHypoglycemia unawarenessT1DM individualsEpinephrine levelsBrain transportControl groupType 1 diabetes mellitusDefective glucose counterregulationHealthy nondiabetic controlsSevere hypoglycemia unawarenessIntensive insulin therapyLong-term complicationsHospital research unitEntire study populationT1DM participantsAutonomic failureGlucose counterregulationInsulin therapyDiabetes mellitusNondiabetic controlsCerebral cortexAcute hypoglycemiaT1DM controlsCerebral energeticsStudy population
2010
High prevalence of diabetes and pre‐diabetes in adults with Williams syndrome
Pober BR, Wang E, Caprio S, Petersen KF, Brandt C, Stanley T, Osborne LR, Dzuria J, Gulanski B. High prevalence of diabetes and pre‐diabetes in adults with Williams syndrome. American Journal Of Medical Genetics Part C Seminars In Medical Genetics 2010, 154C: 291-298. PMID: 20425788, PMCID: PMC2882962, DOI: 10.1002/ajmg.c.30261.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testHigh prevalenceStandard oral glucose tolerance testMedian insulin levelsPre-diabetic stateAbnormal glucose metabolismPresence of diabetesWilliams syndromeImpaired glucose regulationImpaired glucose toleranceGlucose tolerance testStandard medical practiceWS subjectsGlucose toleranceGlucose areaInsulin levelsTolerance testMean glucoseGlucose curveMouse modelInsulin releaseDiagnostic criteriaGlucose metabolismDiabetesGlucose regulation
2004
Two measures of insulin sensitivity provided similar information in a U.S. population
Bravata DM, Wells CK, Concato J, Kernan WN, Brass LM, Gulanski BI. Two measures of insulin sensitivity provided similar information in a U.S. population. Journal Of Clinical Epidemiology 2004, 57: 1214-1217. PMID: 15567640, DOI: 10.1016/j.jclinepi.2004.05.001.Peer-Reviewed Original Research