Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort.
Rasouli N, Younes N, Utzschneider KM, Inzucchi SE, Balasubramanyam A, Cherrington AL, Ismail-Beigi F, Cohen RM, Olson DE, DeFronzo RA, Herman WH, Lachin JM, Kahn SE, Crandall J, McKee M, Brown-Friday J, Xhori E, Ballentine-Cargill K, Duran S, Lukin J, Beringher S, de la torre S, Phillips L, Burgess E, Olson D, Rhee M, Wilson P, Raines T, Costello J, Gullett C, Maher-Albertelli M, Morehead F, Mungara R, Person S, Savoye L, Sibymon M, Tanukonda S, Ann White C, Holloway L, Adams C, Ross A, Balasubramanyam A, Gonzalez E, Wright C, Hollander P, Roe E, Uy A, Burt P, Estrada L, Chionh K, Ismail-Beigi F, Falck-Ytter C, Kassem L, Sood A, Tiktin M, Cramer B, Iacoboni J, Kononets M, Kulow T, Newman C, Stancil K, Sanders C, Tucker L, Werner A, Krol A, McPhee G, Patel C, Colosimo L, Goland R, Pring J, Kringas P, Tejada J, Hausheer C, Schneier H, Gumpel K, Kirpitch A, Green J, AbouAssi H, Chatterjee R, Feinglos M, Jones J, Khan S, Kimpel J, Zimmer R, Furst M, Satterwhite B, Thacker C, Kreider K, Mather K, Lteif A, Hamilton T, Patel N, Riera G, Jackson M, Pirics V, Howard D, Aguillar D, Hurt S, Bergenstal R, Carlson A, Martens T, Johnson M, Hill R, Hyatt J, Jensen C, Madden M, Martin D, Willis H, Konerza W, Passi R, Kleeberger K, Fortmann S, Herson M, Mularski K, Glauber H, Prihoda J, Ash B, Carlson C, Ramey P, Schield E, Torgrimson-Ojerio B, Arnold K, Kauffman B, Panos E, Sahnow S, Bays K, Cook J, Gluth J, Sasaki D, Schell K, Criscola J, Friason C, Jones S, Nazarov S, Barzilay J, Rassouli N, Puttnam R, Curtis M, Stokes K, Hollis B, Sanders-Jones C, Nelson R, El-Haqq Z, Kolli A, Tran T, Wexler D, Larkin M, Meigs J, Dushkin A, Rocchio G, Chambers B, Yepes M, Steiner B, Dulin H, Cayford M, DeManbey A, Gurry L, Hillard M, Martin K, Stevens C, Thangthaeng N, Kochis R, Raymond E, Ripley V, Park J, Aroda V, Ghazi A, Loveland A, Hurtado M, Kuhn A, Mofor F, Florez H, Valencia W, Marks J, Oropesa-Gonzalez L, Riccio Veliz A, Nieto-Martinez R, Gutt M, Ahmann A, Aby-Daniel D, Joarder F, Morimoto V, Sprague C, Yamashita D, Cady N, Kirchhoff P, Rivera-Eschright N, Adducci J, Gomez B, Goncharova A, Hox S, Petrovitch H, Matwichyna M, Jenkins V, Bermudez N, Ishii R, Hsia D, Cefalu W, Greenway F, Waguespack C, King E, Haynes N, Thomassie A, Bourgeois B, Hazlett C, Henry R, Mudaliar S, Boeder S, Pettus J, Diaz E, DeLue C, Castro E, Hernandez S, Krakoff J, Curtis J, Killean T, Joshevama E, Diaz E, Martin D, Karshner T, Albu J, Pi-Sunyer F, Frances S, Maggio C, Ellis E, Bastawrose J, Gong X, Banerji M, August P, Lorber D, Brown N, Josephson D, Thomas L, Tsovian M, Cherian A, Jacobson M, Mishko M, Kirkman M, Bergamo K, Buse J, Dostou J, Young L, Goley A, Kerr J, Largay J, Guarda S, Cuffee J, Culmer D, Fraser R, Almeida H, Coffer S, Debnam E, Kiker L, Morton S, Garvey K, Fuller G, Garvey W, Cherrington A, Golson D, Griffith O, Catherine M, Agne A, McCullars S, Cohen R, Craig J, Kersey K, Rogge M, Wilson C, Burton K, Lipp S, Mary Beth V, Rasouli N, Schroeder E, Steiner S, Baker C, Underkofler C, Douglass S, Sivitz W, Cline E, Knosp L, McConnell J, Lowe T, Herman W, Pop-Busui R, Tan M, Martin C, Waltje A, Goodhall L, Eggleston R, Kuo S, Bule S, Kessler N, LaSalle E, Seaquist E, Bantle A, Kumar A, Redmon B, Bantle J, Harindhanavudhi T, Coe M, Mech M, Taddese A, Lesne L, Smitha S, Desouz C, Kuechenmeister L, Shivaswamy V, Morales A, Rodriguez M, Seipel K, Alfred A, Eggert J, Lord G, Taylor W, Tillson R, Schade D, Adolphe A, Burge M, Duran-Valdez E, Martinez J, Hernandez McGinnis D, Pucchetti B, Scripsick E, DeFronzo R, Cersosimo E, Abdul-Ghani M, Triplitt C, Verastiqui H, Garza R, Wright K, Puckett C, Raskin P, Rhee C, Abraham S, Jordan L, Sao S, Morton L, Smith O, Osornio Walker L, Schnurr-Breen L, Ayala R, Kraymer R, Sturgess D, Utzschneider K, Kahn S, Alarcon-Casas Wright L, Boyko E, Tsai E, Trence D, Fattaleh B, Montgomery B, Atkinson K, Concepcion T, Kozedub A, Moak C, Rhothisen S, Elasy T, Martin S, Shackelford L, Goidel R, Hinkle N, Lipps Hogan J, Lovell C, Myers J, McGill J, Salam M, Kissel S, Schweiger T, Recklein C, Tamborlane W, Gatcomb P, Camp A, Gulanski B, Inzucchi S, Pham K, Alguard M, Lessard K, Perez M, Magenheimer E, Montoza A, Nathan D, Nathan D, Lachin J, Buse J, Kahn S, Krause-Steinrauf H, Larkin M, Tiktin M, Wexler D, Burch H, Linder B, Bremer A, Lachin J, Krause-Steinrauf H, Younes N, Backman M, Bebu I, Buys C, Fagan Murphy A, Gao Y, Gramzinski M, Hall S, Legowski E, Arey A, Bethepu J, Lund C, Mangat Dhaliwal P, McGee P, Mesimer E, Ngo L, Steffes M, Seegmiller J, Saenger A, Arends V, Gabrielson D, Conner T, Warren S, Day J, Scrymgeour A, Soliman E, Zhang Z, Campbell C, Hu J, Keasler L, Hensley S, Li Y, Herman W, Martin C, Waltje A, Kuo S, Mihalcea R, Perez-Rosas V, Prosser L, Resnicow K, Ye W, Shao H, Zhang P, Luchsinger J, Sanchez D, Burch H, Bremer A, Linder B, Fradkin J, Groessl E, Chong H, Hillery N, Abdouch I, Brantley P, Broyles F, Canaris G, Copeland P, Craine J, Fein W, Lee M, Meiners R, Meiners V, O’Neal H, Park J, Sledge E, Steppel-Resnick J, Turchin A, Brooks-Worrell B, Hampe C, Newgard C, Palmer J, Shojaie A, Higgins J, Fischer L, Golden S, Gonzalez J, Naik A, Walker E, Doner Lotenberg L, Gallivan J, Lim J, Tuncer D, Behringer-Massera S. Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort. Diabetes Care 2020, 44: 340-349. PMID: 33334808, PMCID: PMC7818323, DOI: 10.2337/dc20-1787.Peer-Reviewed Original ResearchConceptsΒ-cell functionTG/HDLBlack/African AmericanAmerican Indians/Alaska NativesDisposition indexInsulin sensitivityHigher HbAOral glucose tolerance testAfrican AmericansGlycemia Reduction ApproachesHigher disposition indexHDL cholesterol ratioAlaska NativesGlucose tolerance testOral disposition indexC-peptide indexSimilar insulin sensitivityType 2 diabetesYears of ageCross-sectional analysisBMI 34.2Metformin monotherapyBaseline characteristicsInsulinogenic indexLower HbAOptimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight
Sivitz W, Phillips L, Wexler D, Fortmann S, Camp A, Tiktin M, Perez M, Craig J, Hollander P, Cherrington A, Aroda V, Tan M, Krakoff J, Rasouli N, Butera N, Younes N, Crandall J, Diane McKee M, Brown-Friday J, Xhori E, Ballentine-Cargill K, Duran S, Lukin J, Beringher S, Gonzalez de la torre S, Phillips L, Burgess E, Olson D, Rhee M, Wilson P, Stephanie Raines T, Costello J, Gullett C, Maher-Albertelli M, Morehead F, Mungara R, Person S, Savoye L, Sibymon M, Tanukonda S, Ann White C, Holloway L, Adams C, Ross A, Balasubramanyam A, Gonzalez E, Wright C, Hollander P, Roe E, Uy A, Burt P, Estrada L, Chionh K, Ismail-Beigi F, Falck-Ytter C, Sayyed Kassem L, Sood A, Tiktin M, Cramer B, Iacoboni J, Kononets M, Kulow T, Newman C, Stancil K, Sanders C, Tucker L, Werner A, Krol A, McPhee G, Patel C, Colosimo L, Goland R, Pring J, Kringas P, Tejada J, Hausheer C, Schneier H, Gumpel K, Kirpitch A, Green J, AbouAssi H, Chatterjee R, Feinglos M, English Jones J, Khan S, Kimpel J, Zimmer R, Furst M, Satterwhite B, Thacker C, Evans Kreider K, Mather K, Lteif A, Hamilton T, Patel N, Riera G, Jackson M, Pirics V, Howard D, Aguillar D, Hurt S, Bergenstal R, Carlson A, Martens T, Johnson M, Hill R, Hyatt J, Jensen C, Madden M, Martin D, Willis H, Konerza W, Passi R, Kleeberger K, Fortmann S, Herson M, Mularski K, Glauber H, Prihoda J, Ash B, Carlson C, Anne Ramey P, Schield E, Torgrimson-Ojerio B, Arnold K, Kauffman B, Panos E, Sahnow S, Bays K, Cook J, Gluth J, Sasaki D, Schell K, Criscola J, Friason C, Jones S, Nazarov S, Barzilay J, Rassouli N, Puttnam R, Curtis M, Stokes K, Hollis B, Sanders-Jones C, Nelson R, El-Haqq Z, Kolli A, Tran T, Wexler D, Mary L, Meigs J, Dushkin A, Rocchio G, Chambers B, Yepes M, Steiner B, Dulin H, Cayford M, DeManbey A, Gurry L, Hillard M, Martin K, Stevens C, Thangthaeng N, Kochis R, Raymond E, Ripley V, Park J, Aroda V, Ghazi A, Loveland A, Hurtado M, Kuhn A, Mofor F, Florez H, Valencia W, Marks J, Oropesa-Gonzalez L, Riccio Veliz A, Nieto-Martinez R, Gutt M, Ahmann A, Aby-Daniel D, Joarder F, Morimoto V, Sprague C, Yamashita D, Cady N, Kirchhoff P, Rivera-Eschright N, Adducci J, Gomez B, Goncharova A, Hox S, Petrovitch H, Matwichyna M, Jenkins V, Bermudez N, Ishii R, Hsia D, Cefalu W, Greenway F, Waguespack C, King E, Haynes N, Thomassie A, Bourgeois B, Hazlett C, Henry R, Mudaliar S, Boeder S, Pettus J, Diaz E, DeLue C, Castro E, Hernandez S, Krakoff J, Curtis J, Killean T, Joshevama E, Diaz E, Martin D, Karshner T, Albu J, Pi-Sunyer F, Frances S, Maggio C, Ellis E, Bastawrose J, Gong X, Ann Banerji M, August P, Lorber D, Brown N, Josephson D, Thomas L, Tsovian M, Cherian A, Jacobson M, Mishko M, Kirkman M, Bergamo K, Buse J, Dostou J, Young L, Goley A, Kerr J, Largay J, Guarda S, Cuffee J, Culmer D, Fraser R, Almeida H, Coffer S, Debnam E, Kiker L, Morton S, Josey K, Fuller G, Garvey W, Cherrington A, Golson D, Griffith O, Catherine Robertson M, Agne A, McCullars S, Cohen R, Craig J, Kersey K, Rogge M, Wilson C, Burton K, Lipp S, Vonder Meulen M, Rasouli N, Schroeder E, Steiner S, Baker C, Underkofler C, Douglass S, Sivitz W, Cline E, Knosp L, McConnell J, Lowe T, Herman W, Pop-Busui R, Tan M, Martin C, Waltje A, Goodhall L, Eggleston R, Kuo S, Bule S, Kessler N, LaSalle E, Seaquist E, Bantle A, Kumar A, Redmon B, Bantle J, Harindhanavudhi T, Coe M, Mech M, Taddese A, Lesne L, Smith S, Desouza C, Kuechenmeister L, Shivaswamy V, Laura Morales A, Rodriguez M, Seipel K, Alfred A, Eggert J, Lord G, Taylor W, Tillson R, Schade D, Adolphe A, Burge M, Duran-Valdez E, Martinez J, McGinnis D, Pucchetti B, Scripsick E, DeFronzo R, Cersosimo E, Abdul-Ghani M, Triplitt C, Verastiqui H, Irene Garza R, Wright K, Puckett C, Raskin P, Rhee C, Abraham S, Fan Jordan L, Sao S, Morton L, Smith O, Osornio Walker L, Schnurr-Breen L, Ayala R, Brian Kraymer R, Sturgess D, Utzschneider K, Kahn S, Alarcon-Casas Wright L, Boyko E, Tsai E, Trence D, Fattaleh B, Montgomery B, Atkinson K, Concepcion T, Kozedub A, Moak C, Rhothisen S, Elasy T, Martin S, Shackelford L, Goidel R, Hinkle N, Lipps Hogan J, Lovell C, Myers J, McGill J, Salam M, Kissel S, Schweiger T, Recklein C, Tamborlane W, Gatcomb P, Camp A, Gulanski B, Inzucchi S, Pham K, Alguard M, Lessard K, Perez M, Magenheimer E, Montoza A, Nathan D, Lachin J, Buse J, Kahn S, Krause-Steinrauf H, Larkin M, Tiktin M, Wexler D, Burch H, Linder B, Bremer A, Lachin J, Krause-Steinrauf H, Younes N, Backman M, Bebu I, Buys C, Fagan Murphy A, Gao Y, Gramzinski M, Hall S, Legowski E, Arey A, Bethepu J, Lund C, Mangat Dhaliwal P, McGee P, Mesimer E, Ngo L, Steffes M, Seegmiller J, Saenger A, Arends V, Gabrielson D, Conner T, Warren S, Day J, Scrymgeour A, Soliman E, Zhang Z, Campbell C, Hu J, Keasler L, Hensley S, Li Y, Herman W, Martin C, Waltje A, Kuo S, Mihalcea R, Perez-Rosas V, Prosser L, Resnicow K, Ye W, Shao H, Zhang P, Luchsinger J, Sanchez D, Burch H, Bremer A, Linder B, Fradkin J, Groessl E, Chong H, Hillery N, Abdouch I, Brantley P, Broyles F, Canaris G, Copeland P, Craine J, Fein W, Lee M, Meiners R, Meiners V, O’Neal H, Park J, Sledge E, Steppel-Resnick J, Turchin A, Brooks-Worrell B, Hampe C, Newgard C, Palmer J, Shojaie A, Higgins J, Fischer L, Golden S, Gonzalez J, Naik A, Walker E, Doner Lotenberg L, Gallivan J, Lim J, Tuncer D, Behringer-Massera S. Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight. Diabetes Care 2020, 43: 940-947. PMID: 32139384, PMCID: PMC7171946, DOI: 10.2337/dc19-1769.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood GlucoseBody WeightCalibrationComparative Effectiveness ResearchDiabetes Mellitus, Type 2Dose-Response Relationship, DrugDrug Therapy, CombinationFemaleGlycated HemoglobinHumansHypoglycemic AgentsInsulinLiraglutideMaleMaximum Tolerated DoseMetforminMiddle AgedSitagliptin PhosphateSulfonylurea CompoundsWeight LossConceptsType 2 diabetesLow doseBody weightGlycemia Reduction ApproachesGlucose-lowering drugsSuboptimal glycemic controlExercise counselingMetformin therapyPrespecified analysisGlycemic controlPrimary outcomeMedication adherenceHigher HbASD changeDiabetesMetforminGlycemiaDoseWeight lossHbAGreater reductionDaysParticipantsGrade cohorts