2019
The Combination of Patient-Reported Clinical Symptoms and an Endoscopic Score Correlates Well with Health-Related Quality of Life in Patients with Ulcerative Colitis
Aniwan S, Bruining DH, Park SH, Al-Bawardy B, Kane SV, Prabhu N, Kisiel JB, Raffals LE, Papadakis KA, Pardi DS, Tremaine WJ, Loftus EV. The Combination of Patient-Reported Clinical Symptoms and an Endoscopic Score Correlates Well with Health-Related Quality of Life in Patients with Ulcerative Colitis. Journal Of Clinical Medicine 2019, 8: 1171. PMID: 31387259, PMCID: PMC6723355, DOI: 10.3390/jcm8081171.Peer-Reviewed Original ResearchShort Inflammatory Bowel Disease QuestionnaireMayo endoscopic subscorePatient-reported outcomesUlcerative colitisClinical symptomsPatient-reported clinical symptomsChronic Illness Therapy-FatigueInflammatory Bowel Disease QuestionnaireProspective cross-sectional studyConsecutive UC patientsActivity Impairment QuestionnaireBowel Disease QuestionnaireHealth-related qualityFuture clinical trialsCross-sectional studyCombination of patientQuality of lifeStool frequencyDisease QuestionnaireEndoscopic scoreEndoscopic subscorePrimary endpointRectal bleedingUC patientsHRQoL scores
2018
Vedolizumab Drug Level Correlation With Clinical Remission, Biomarker Normalization, and Mucosal Healing in Inflammatory Bowel Disease
Al-Bawardy B, Ramos GP, Willrich MAV, Jenkins SM, Park SH, Aniwan S, Schoenoff SA, Bruining DH, Papadakis KA, Raffals L, Tremaine WJ, Loftus EV. Vedolizumab Drug Level Correlation With Clinical Remission, Biomarker Normalization, and Mucosal Healing in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2018, 25: 580-586. PMID: 30165638, DOI: 10.1093/ibd/izy272.Peer-Reviewed Original ResearchConceptsMedian vedolizumab trough levelsVedolizumab trough levelsC-reactive proteinInflammatory bowel diseaseNormal C-reactive proteinMucosal healingCrohn's diseaseUC patientsBowel diseaseTrough levelsUlcerative colitisClinical managementFourth of patientsTrough level measurementMayo endoscopic scoreCross-sectional studyHigh CRP patientsBiomarker normalizationIBD patientsClinical remissionCRP patientsEndoscopic scoreMucosal ulcersDetectable antibodiesBACKGROUND/