2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imagingPositron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmHuman aortic tissueMMP activityAortic tissueAortic aneurysmMMP inhibitorsMurine modelMatrix metalloproteinasesPositron emission tomography/Toxicology studiesAortic MMP activityPositron emission tomography radioligandAngiotensin II infusionEmission tomography/Murine abdominal aortic aneurysmsBroad-spectrum MMP inhibitorMatrix metalloproteinase activityPositron emission tomography (PET) tracerPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyEmission tomography tracerII infusionRisk stratificationTomography/
2017
Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading
Seidel T, Navankasattusas S, Ahmad A, Diakos N, Xu W, Tristani-Firouzi M, Bonios M, Taleb I, Li D, Selzman C, Drakos S, Sachse F. Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading. Circulation 2017, 135: 1632-1645. PMID: 28073805, PMCID: PMC5404964, DOI: 10.1161/circulationaha.116.024470.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiopsyCase-Control StudiesEchocardiographyExcitation Contraction CouplingFemaleHeart FailureHeart-Assist DevicesHumansImage Processing, Computer-AssistedMaleMicroscopy, ConfocalMiddle AgedMyocardial ContractionMyocytes, CardiacProspective StudiesProsthesis DesignRecovery of FunctionRyanodine Receptor Calcium Release ChannelTime FactorsTreatment OutcomeVentricular Function, LeftVentricular RemodelingConceptsLeft ventricular assist deviceChronic heart failureHeart failureExcitation-contraction couplingCardiac recoveryMechanical unloadingLVAD implantationEjection fractionFunctional recoveryHF myocytesImplantation of LVADHallmark of HFHuman end-stage heart failureLeft ventricular ejection fractionEnd-stage heart failureTransverse tubular systemEnd-stage human heart failureEjection fraction increaseIsolated human cardiomyocytesVentricular ejection fractionSubgroup of patientsVolume/length ratioHuman heart failureFunctional cardiac recoveryVentricular assist device