2023
Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review
Zhornitsky S, Oliva H, Jayne L, Allsop A, Kaye A, Potenza M, Angarita G. Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review. Frontiers In Psychiatry 2023, 14: 1197890. PMID: 37435405, PMCID: PMC10331617, DOI: 10.3389/fpsyt.2023.1197890.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAdministration of ketamineSynaptic markersSubstance use disordersPrefrontal cortexSingle doseBasal conditionsStress-related reductionPsilocybin/psilocinVerbal memory performanceWeb of ScienceKetamine treatmentSystematic scoping reviewLysergic acid diethylamideSynaptic densityClinical studiesSynaptophysin 1PRISMA guidelinesSynapsin 1Use disordersPlace preferenceAbuse liabilitySynaptic changesKetaminePSD-95Study design
2022
Stepping Out of the Palace of Luxury: Mindfulness and Modern Psychiatry
Allsop AS, Chaudhry HW, Novick AM, Ross DA. Stepping Out of the Palace of Luxury: Mindfulness and Modern Psychiatry. Biological Psychiatry 2022, 92: e5-e7. PMID: 35772908, PMCID: PMC9516782, DOI: 10.1016/j.biopsych.2022.05.015.Peer-Reviewed Original Research
2021
Understanding the Role of a Molecularly Defined Social Circuit
Pruitt A, Allsop AS. Understanding the Role of a Molecularly Defined Social Circuit. Biological Psychiatry 2021, 89: 421-423. PMID: 33541524, DOI: 10.1016/j.biopsych.2020.12.017.Peer-Reviewed Original ResearchDecriminalising being Black with mental illness
Jordan A, Allsop AS, Collins PY. Decriminalising being Black with mental illness. The Lancet Psychiatry 2021, 8: 8-9. PMID: 33341173, DOI: 10.1016/s2215-0366(20)30519-8.Peer-Reviewed Original Research
2019
Sequential Detection of Regime Changes in Neural Data
Banerjee T, Allsop S, Tye K, Ba D, Tarokh V. Sequential Detection of Regime Changes in Neural Data. 2019, 00: 139-142. DOI: 10.1109/ner.2019.8716926.Peer-Reviewed Original Research
2018
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Allsop S, Wichmann R, Mills F, Burgos-Robles A, Chang C, Felix-Ortiz A, Vienne A, Beyeler A, Izadmehr E, Glober G, Cum M, Stergiadou J, Anandalingam K, Farris K, Namburi P, Leppla C, Weddington J, Nieh E, Smith A, Ba D, Brown E, Tye K. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell 2018, 173: 1329-1342.e18. PMID: 29731170, PMCID: PMC6345560, DOI: 10.1016/j.cell.2018.04.004.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexObservational fear conditioningFear conditioningBasolateral amygdalaThreat-predictive stimuliAssociative fear conditioningImpaired acquisitionAversive cuesCingulate cortexPredictive cuesDemonstrator mouseCue informationAversive valueObservational learningCuesElectrophysiological recordingsRouting of informationAmygdalaCortexMiceStimuliPunishmentSurvival toolInhibitionEstimating a Separably Markov Random Field from Binary Observations
Zhang Y, Malem-Shinitski N, Allsop S, Tye K, Ba D. Estimating a Separably Markov Random Field from Binary Observations. Neural Computation 2018, 30: 1046-1079. PMID: 29381446, DOI: 10.1162/neco_a_01059.Peer-Reviewed Original ResearchConceptsNeural spiking dataMarkov random fieldLimitation of current methodsLoss of informationSpike dataNeural spikesConditional intensity functionRandom fieldState sequenceRF modelLearning of fearLearningTrial-to-trial dynamicsConditioned stimulusEstimate state-space modelsNeuronsPrefrontal cortexNeural underpinningsAssociative learningBinary observationsComputational toolsNeural activityIntensity functionTrialsCurrent methods
2017
Endocannabinoid Signaling in the Control of Social Behavior
Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid Signaling in the Control of Social Behavior. Trends In Neurosciences 2017, 40: 385-396. PMID: 28554687, PMCID: PMC5699224, DOI: 10.1016/j.tins.2017.04.005.Peer-Reviewed Original ResearchConceptsSocial behaviorEndocannabinoid signalingG-protein-coupled cannabinoid receptorsEndocannabinoid signaling systemComplex social groupsSocial anxietySocial impairmentNeural basisSocial rewardsCannabinoid receptorsNeural processesEndocannabinoidAnimal modelsEmergent insightsAnxietyRewardBehaviorSocial groupsImpairmentBrainSignaling systemAgonistsMammalian speciesReceptors
2015
Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Goldberg J, Fisher D, Demetri G, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut C, George S, Morgan J, Wagner A, Freeman G, Ritz J, Lezcano C, Mihm M, Canning C, Hodi F, Dranoff G. Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clinical Cancer Research 2015, 21: 3178-3186. PMID: 25805798, PMCID: PMC4506240, DOI: 10.1158/1078-0432.ccr-14-2932.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaClear cell sarcomaGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSoft part sarcomaTissue-type plasminogen activatorMicrophthalmia transcription factorGM-CSFReplication-defective adenoviral vector encoding GM-CSFSecrete granulocyte-macrophage colony-stimulating factorCCS patientsImmune-mediated tumor destructionT-cell-mediated delayed-type hypersensitivity reactionCD8(+) T cellsAdenoviral-mediated gene transferPhase I clinical trialDelayed-type hypersensitivity reactionAutologous tumor cellsPD-ligand 1Sarcoma cellsNo tumor regressionRare mesenchymal malignancySingle-cell suspensionsTumor regressionMetastatic tumorsDecoding Neural Circuits that Control Compulsive Sucrose Seeking
Nieh E, Matthews G, Allsop S, Presbrey K, Leppla C, Wichmann R, Neve R, Wildes C, Tye K. Decoding Neural Circuits that Control Compulsive Sucrose Seeking. Cell 2015, 161: 1468-1471. DOI: 10.1016/j.cell.2015.05.037.Peer-Reviewed Original ResearchDecoding Neural Circuits that Control Compulsive Sucrose Seeking
Nieh E, Matthews G, Allsop S, Presbrey K, Leppla C, Wichmann R, Neve R, Wildes C, Tye K. Decoding Neural Circuits that Control Compulsive Sucrose Seeking. Cell 2015, 160: 528-541. PMID: 25635460, PMCID: PMC4312417, DOI: 10.1016/j.cell.2015.01.003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVentral tegmental area dopamineNeural circuitsReward-predictive cuesFeeding-related behaviorsSucrose seekingReward omissionReward processingReward availabilityTegmental areaHungry miceGABA neuronsLH neuronsGABAergic projectionsDopamineRewardLearning actionsInhibitory inputsNeuronsTherapeutic interventionsSeekingCuesDisordersGABAFood consumption
2014
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop S, Vander Weele C, Wichmann R, Tye K. Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. Frontiers In Behavioral Neuroscience 2014, 8: 241. PMID: 25076878, PMCID: PMC4099964, DOI: 10.3389/fnbeh.2014.00241.Peer-Reviewed Original ResearchAnxiety-related behaviorAutism spectrum disorderAnxiety disordersSocial deficitsSocial behaviorBasolateral amygdalaVentral hippocampusSpectrum disorderPathogenesis of social anxiety disorderModulating anxiety-related behaviorsRates of co-morbiditySocial anxiety disorderModulate social behaviorPsychiatric disease statesNeural circuit mechanismsComplex emotional statesPsychiatric illnessPsychiatric diseasesInvestigation of neural circuitsCircuit mechanismsAnxietyNeural circuitsEmotional statesSocial domainsDeficits
2013
Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain
Bojarski E, Strauss A, Fagin A, Plantinga T, Hoischen A, Veltman J, Allsop S, Granadillo V, William A, Netea M, Dimitrakoff J. Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain. PLOS ONE 2013, 8: e68118. PMID: 23861857, PMCID: PMC3704649, DOI: 10.1371/journal.pone.0068118.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphotericin BAntifungal AgentsBase SequenceChronic DiseaseClass Ib Phosphatidylinositol 3-KinaseDNA Mutational AnalysisExomeFlow CytometryGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunoglobulins, IntravenousLeukocyte CountMaleMolecular Sequence DataMutationPelvic PainReproducibility of ResultsConceptsChronic pelvic painPelvic painChronic infectionChronic purulent sinusitisLong-term treatment regimensCellular immune responsesAntifungal therapyPurulent sinusitisCandida speciesTreatment regimensProstatic fluidWork-upImmune responseSymptom improvementMissense mutationsLeukocyte functionRas-binding domainPainDebilitating symptomsInfectionMutationsSymptomsSignaling elementsRegimensRash
2012
Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis
Yang W, Rudick C, Hoxha E, Allsop S, Dimitrakoff J, Klumpp D. Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis. American Journal Of Physiology. Renal Physiology 2012, 303: f350-f356. PMID: 22647634, PMCID: PMC3433862, DOI: 10.1152/ajprenal.00077.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2CystitisDose-Response Relationship, DrugFemaleHerpesvirus 1, SuidHyperalgesiaImage Processing, Computer-AssistedImmunohistochemistryInjections, SpinalIsoenzymesMiceMice, Inbred C57BLMicroarray AnalysisPelvic PainPhosphorylationPosterior Horn CellsReal-Time Polymerase Chain ReactionRNARNA, MessengerSpinal CordTranscription, GeneticConceptsSacral spinal cordPelvic painNeurogenic cystitisProtein kinase IISpinal cordDorsal hornAssociated with urothelial lesionsChronic bladder inflammatory diseaseDevelopment of pelvic painMurine neurogenic cystitis modelCaMKII inhibitor KN-93Interstitial cystitis/painful bladder syndromeAssociated with pelvic painCa(2+)/calmodulin-dependent protein kinase IIAbductor caudalis dorsalisProgressive pelvic painPostinfection dayKinase IIInhibitor KN-93Pain-signaling pathwaysFemale C57BL/6J miceCa2+/calmodulin-dependent protein kinase IIPostinfection day 2Pelvic/perineal areaCystitis model
2011
The Role of Phenotyping in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Mahal BA, Cohen JM, Allsop SA, Moore JB, Bhai SF, Inverso G, Dimitrakoff JD. The Role of Phenotyping in Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Current Urology Reports 2011, 12: 297-303. PMID: 21533747, DOI: 10.1007/s11934-011-0196-y.Peer-Reviewed Original ResearchConceptsChronic prostatitis/chronic pelvic pain syndromeChronic pelvic pain syndromeCP/CPPSPelvic pain syndromePain syndromeChronic pain syndromeCurrent symptom-based diagnosesSymptom-based diagnosisUnderlying biological mechanismsTreatment approachesClinical approachCurrent diagnosisSyndromeSuccessful managementDiagnosisTreatmentBiological mechanismsCPPSPainPathogenesisSymptomsMonthsThe oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells
Xu D, Allsop S, Witherspoon S, Snider J, Yeh J, Fiordalisi J, White C, Williams D, Cox A, Baines A. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis 2011, 32: 488-495. PMID: 21262926, PMCID: PMC3066419, DOI: 10.1093/carcin/bgr007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBcl-Associated Death ProteinCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p27HumansNeoplasm InvasivenessPancreatic NeoplasmsPhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-pim-1Proto-Oncogene Proteins p21(ras)Radiation ToleranceRas ProteinsSignal TransductionConceptsShRNA-mediated suppressionK-Ras signalingPim-1 expressionPancreatic ductal adenocarcinoma cell linesPim-1 kinasePro-apoptotic protein BadCell growthOncogenic K-Ras signalingK-rasPim-1 protein levelsCyclin-dependent kinase inhibitor p27Kip1Immortalized cell modelGrowth transformationHuman pancreatic ductal adenocarcinoma cellsCell linesPancreatic ductal adenocarcinomaPim-1Pancreatic ductal adenocarcinoma cell growthMutant K-rasPim-1 activityPim-1 proteinProtein BadOncogenic K-RasPancreatic ductal adenocarcinoma cellsKinase activityThe DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS
Allsop SA, Erstad DJ, Brook K, Bhai SF, Cohen JM, Dimitrakoff JD. The DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS. Nature Reviews Urology 2011, 8: 107-113. PMID: 21243018, DOI: 10.1038/nrurol.2010.227.Peer-Reviewed Original Research