2021
Understanding the Role of a Molecularly Defined Social Circuit
Pruitt A, Allsop AS. Understanding the Role of a Molecularly Defined Social Circuit. Biological Psychiatry 2021, 89: 421-423. PMID: 33541524, DOI: 10.1016/j.biopsych.2020.12.017.Peer-Reviewed Original Research
2018
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Allsop S, Wichmann R, Mills F, Burgos-Robles A, Chang C, Felix-Ortiz A, Vienne A, Beyeler A, Izadmehr E, Glober G, Cum M, Stergiadou J, Anandalingam K, Farris K, Namburi P, Leppla C, Weddington J, Nieh E, Smith A, Ba D, Brown E, Tye K. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell 2018, 173: 1329-1342.e18. PMID: 29731170, PMCID: PMC6345560, DOI: 10.1016/j.cell.2018.04.004.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexObservational fear conditioningFear conditioningBasolateral amygdalaThreat-predictive stimuliAssociative fear conditioningImpaired acquisitionAversive cuesCingulate cortexPredictive cuesDemonstrator mouseCue informationAversive valueObservational learningCuesElectrophysiological recordingsRouting of informationAmygdalaCortexMiceStimuliPunishmentSurvival toolInhibitionEstimating a Separably Markov Random Field from Binary Observations
Zhang Y, Malem-Shinitski N, Allsop S, Tye K, Ba D. Estimating a Separably Markov Random Field from Binary Observations. Neural Computation 2018, 30: 1046-1079. PMID: 29381446, DOI: 10.1162/neco_a_01059.Peer-Reviewed Original ResearchConceptsNeural spiking dataMarkov random fieldLimitation of current methodsLoss of informationSpike dataNeural spikesConditional intensity functionRandom fieldState sequenceRF modelLearning of fearLearningTrial-to-trial dynamicsConditioned stimulusEstimate state-space modelsNeuronsPrefrontal cortexNeural underpinningsAssociative learningBinary observationsComputational toolsNeural activityIntensity functionTrialsCurrent methods
2015
Decoding Neural Circuits that Control Compulsive Sucrose Seeking
Nieh E, Matthews G, Allsop S, Presbrey K, Leppla C, Wichmann R, Neve R, Wildes C, Tye K. Decoding Neural Circuits that Control Compulsive Sucrose Seeking. Cell 2015, 160: 528-541. PMID: 25635460, PMCID: PMC4312417, DOI: 10.1016/j.cell.2015.01.003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVentral tegmental area dopamineNeural circuitsReward-predictive cuesFeeding-related behaviorsSucrose seekingReward omissionReward processingReward availabilityTegmental areaHungry miceGABA neuronsLH neuronsGABAergic projectionsDopamineRewardLearning actionsInhibitory inputsNeuronsTherapeutic interventionsSeekingCuesDisordersGABAFood consumption