2018
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning
Allsop S, Wichmann R, Mills F, Burgos-Robles A, Chang C, Felix-Ortiz A, Vienne A, Beyeler A, Izadmehr E, Glober G, Cum M, Stergiadou J, Anandalingam K, Farris K, Namburi P, Leppla C, Weddington J, Nieh E, Smith A, Ba D, Brown E, Tye K. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell 2018, 173: 1329-1342.e18. PMID: 29731170, PMCID: PMC6345560, DOI: 10.1016/j.cell.2018.04.004.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexObservational fear conditioningFear conditioningBasolateral amygdalaThreat-predictive stimuliAssociative fear conditioningImpaired acquisitionAversive cuesCingulate cortexPredictive cuesDemonstrator mouseCue informationAversive valueObservational learningCuesElectrophysiological recordingsRouting of informationAmygdalaCortexMiceStimuliPunishmentSurvival toolInhibition
2015
Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Goldberg J, Fisher D, Demetri G, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut C, George S, Morgan J, Wagner A, Freeman G, Ritz J, Lezcano C, Mihm M, Canning C, Hodi F, Dranoff G. Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clinical Cancer Research 2015, 21: 3178-3186. PMID: 25805798, PMCID: PMC4506240, DOI: 10.1158/1078-0432.ccr-14-2932.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaClear cell sarcomaGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSoft part sarcomaTissue-type plasminogen activatorMicrophthalmia transcription factorGM-CSFReplication-defective adenoviral vector encoding GM-CSFSecrete granulocyte-macrophage colony-stimulating factorCCS patientsImmune-mediated tumor destructionT-cell-mediated delayed-type hypersensitivity reactionCD8(+) T cellsAdenoviral-mediated gene transferPhase I clinical trialDelayed-type hypersensitivity reactionAutologous tumor cellsPD-ligand 1Sarcoma cellsNo tumor regressionRare mesenchymal malignancySingle-cell suspensionsTumor regressionMetastatic tumors
2013
Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain
Bojarski E, Strauss A, Fagin A, Plantinga T, Hoischen A, Veltman J, Allsop S, Granadillo V, William A, Netea M, Dimitrakoff J. Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain. PLOS ONE 2013, 8: e68118. PMID: 23861857, PMCID: PMC3704649, DOI: 10.1371/journal.pone.0068118.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphotericin BAntifungal AgentsBase SequenceChronic DiseaseClass Ib Phosphatidylinositol 3-KinaseDNA Mutational AnalysisExomeFlow CytometryGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunoglobulins, IntravenousLeukocyte CountMaleMolecular Sequence DataMutationPelvic PainReproducibility of ResultsConceptsChronic pelvic painPelvic painChronic infectionChronic purulent sinusitisLong-term treatment regimensCellular immune responsesAntifungal therapyPurulent sinusitisCandida speciesTreatment regimensProstatic fluidWork-upImmune responseSymptom improvementMissense mutationsLeukocyte functionRas-binding domainPainDebilitating symptomsInfectionMutationsSymptomsSignaling elementsRegimensRash
2011
The Role of Phenotyping in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Mahal BA, Cohen JM, Allsop SA, Moore JB, Bhai SF, Inverso G, Dimitrakoff JD. The Role of Phenotyping in Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Current Urology Reports 2011, 12: 297-303. PMID: 21533747, DOI: 10.1007/s11934-011-0196-y.Peer-Reviewed Original ResearchConceptsChronic prostatitis/chronic pelvic pain syndromeChronic pelvic pain syndromeCP/CPPSPelvic pain syndromePain syndromeChronic pain syndromeCurrent symptom-based diagnosesSymptom-based diagnosisUnderlying biological mechanismsTreatment approachesClinical approachCurrent diagnosisSyndromeSuccessful managementDiagnosisTreatmentBiological mechanismsCPPSPainPathogenesisSymptomsMonthsThe DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS
Allsop SA, Erstad DJ, Brook K, Bhai SF, Cohen JM, Dimitrakoff JD. The DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS. Nature Reviews Urology 2011, 8: 107-113. PMID: 21243018, DOI: 10.1038/nrurol.2010.227.Peer-Reviewed Original Research