Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain
Bojarski E, Strauss A, Fagin A, Plantinga T, Hoischen A, Veltman J, Allsop S, Granadillo V, William A, Netea M, Dimitrakoff J. Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain. PLOS ONE 2013, 8: e68118. PMID: 23861857, PMCID: PMC3704649, DOI: 10.1371/journal.pone.0068118.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphotericin BAntifungal AgentsBase SequenceChronic DiseaseClass Ib Phosphatidylinositol 3-KinaseDNA Mutational AnalysisExomeFlow CytometryGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunoglobulins, IntravenousLeukocyte CountMaleMolecular Sequence DataMutationPelvic PainReproducibility of ResultsConceptsChronic pelvic painPelvic painChronic infectionChronic purulent sinusitisLong-term treatment regimensCellular immune responsesAntifungal therapyPurulent sinusitisCandida speciesTreatment regimensProstatic fluidWork-upImmune responseSymptom improvementMissense mutationsLeukocyte functionRas-binding domainPainDebilitating symptomsInfectionMutationsSymptomsSignaling elementsRegimensRash