2021
Decriminalising being Black with mental illness
Jordan A, Allsop AS, Collins PY. Decriminalising being Black with mental illness. The Lancet Psychiatry 2021, 8: 8-9. PMID: 33341173, DOI: 10.1016/s2215-0366(20)30519-8.Peer-Reviewed Original Research
2018
Estimating a Separably Markov Random Field from Binary Observations
Zhang Y, Malem-Shinitski N, Allsop S, Tye K, Ba D. Estimating a Separably Markov Random Field from Binary Observations. Neural Computation 2018, 30: 1046-1079. PMID: 29381446, DOI: 10.1162/neco_a_01059.Peer-Reviewed Original ResearchConceptsNeural spiking dataMarkov random fieldLimitation of current methodsLoss of informationSpike dataNeural spikesConditional intensity functionRandom fieldState sequenceRF modelLearning of fearLearningTrial-to-trial dynamicsConditioned stimulusEstimate state-space modelsNeuronsPrefrontal cortexNeural underpinningsAssociative learningBinary observationsComputational toolsNeural activityIntensity functionTrialsCurrent methods
2017
Endocannabinoid Signaling in the Control of Social Behavior
Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid Signaling in the Control of Social Behavior. Trends In Neurosciences 2017, 40: 385-396. PMID: 28554687, PMCID: PMC5699224, DOI: 10.1016/j.tins.2017.04.005.Peer-Reviewed Original ResearchConceptsSocial behaviorEndocannabinoid signalingG-protein-coupled cannabinoid receptorsEndocannabinoid signaling systemComplex social groupsSocial anxietySocial impairmentNeural basisSocial rewardsCannabinoid receptorsNeural processesEndocannabinoidAnimal modelsEmergent insightsAnxietyRewardBehaviorSocial groupsImpairmentBrainSignaling systemAgonistsMammalian speciesReceptors
2015
Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Goldberg J, Fisher D, Demetri G, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut C, George S, Morgan J, Wagner A, Freeman G, Ritz J, Lezcano C, Mihm M, Canning C, Hodi F, Dranoff G. Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clinical Cancer Research 2015, 21: 3178-3186. PMID: 25805798, PMCID: PMC4506240, DOI: 10.1158/1078-0432.ccr-14-2932.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaClear cell sarcomaGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSoft part sarcomaTissue-type plasminogen activatorMicrophthalmia transcription factorGM-CSFReplication-defective adenoviral vector encoding GM-CSFSecrete granulocyte-macrophage colony-stimulating factorCCS patientsImmune-mediated tumor destructionT-cell-mediated delayed-type hypersensitivity reactionCD8(+) T cellsAdenoviral-mediated gene transferPhase I clinical trialDelayed-type hypersensitivity reactionAutologous tumor cellsPD-ligand 1Sarcoma cellsNo tumor regressionRare mesenchymal malignancySingle-cell suspensionsTumor regressionMetastatic tumors
2013
Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain
Bojarski E, Strauss A, Fagin A, Plantinga T, Hoischen A, Veltman J, Allsop S, Granadillo V, William A, Netea M, Dimitrakoff J. Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain. PLOS ONE 2013, 8: e68118. PMID: 23861857, PMCID: PMC3704649, DOI: 10.1371/journal.pone.0068118.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphotericin BAntifungal AgentsBase SequenceChronic DiseaseClass Ib Phosphatidylinositol 3-KinaseDNA Mutational AnalysisExomeFlow CytometryGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunoglobulins, IntravenousLeukocyte CountMaleMolecular Sequence DataMutationPelvic PainReproducibility of ResultsConceptsChronic pelvic painPelvic painChronic infectionChronic purulent sinusitisLong-term treatment regimensCellular immune responsesAntifungal therapyPurulent sinusitisCandida speciesTreatment regimensProstatic fluidWork-upImmune responseSymptom improvementMissense mutationsLeukocyte functionRas-binding domainPainDebilitating symptomsInfectionMutationsSymptomsSignaling elementsRegimensRash
2011
The Role of Phenotyping in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Mahal BA, Cohen JM, Allsop SA, Moore JB, Bhai SF, Inverso G, Dimitrakoff JD. The Role of Phenotyping in Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Current Urology Reports 2011, 12: 297-303. PMID: 21533747, DOI: 10.1007/s11934-011-0196-y.Peer-Reviewed Original ResearchConceptsChronic prostatitis/chronic pelvic pain syndromeChronic pelvic pain syndromeCP/CPPSPelvic pain syndromePain syndromeChronic pain syndromeCurrent symptom-based diagnosesSymptom-based diagnosisUnderlying biological mechanismsTreatment approachesClinical approachCurrent diagnosisSyndromeSuccessful managementDiagnosisTreatmentBiological mechanismsCPPSPainPathogenesisSymptomsMonthsThe oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells
Xu D, Allsop S, Witherspoon S, Snider J, Yeh J, Fiordalisi J, White C, Williams D, Cox A, Baines A. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis 2011, 32: 488-495. PMID: 21262926, PMCID: PMC3066419, DOI: 10.1093/carcin/bgr007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBcl-Associated Death ProteinCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p27HumansNeoplasm InvasivenessPancreatic NeoplasmsPhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-pim-1Proto-Oncogene Proteins p21(ras)Radiation ToleranceRas ProteinsSignal TransductionConceptsShRNA-mediated suppressionK-Ras signalingPim-1 expressionPancreatic ductal adenocarcinoma cell linesPim-1 kinasePro-apoptotic protein BadCell growthOncogenic K-Ras signalingK-rasPim-1 protein levelsCyclin-dependent kinase inhibitor p27Kip1Immortalized cell modelGrowth transformationHuman pancreatic ductal adenocarcinoma cellsCell linesPancreatic ductal adenocarcinomaPim-1Pancreatic ductal adenocarcinoma cell growthMutant K-rasPim-1 activityPim-1 proteinProtein BadOncogenic K-RasPancreatic ductal adenocarcinoma cellsKinase activityThe DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS
Allsop SA, Erstad DJ, Brook K, Bhai SF, Cohen JM, Dimitrakoff JD. The DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS. Nature Reviews Urology 2011, 8: 107-113. PMID: 21243018, DOI: 10.1038/nrurol.2010.227.Peer-Reviewed Original Research