Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis
Yang W, Rudick C, Hoxha E, Allsop S, Dimitrakoff J, Klumpp D. Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis. American Journal Of Physiology. Renal Physiology 2012, 303: f350-f356. PMID: 22647634, PMCID: PMC3433862, DOI: 10.1152/ajprenal.00077.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2CystitisDose-Response Relationship, DrugFemaleHerpesvirus 1, SuidHyperalgesiaImage Processing, Computer-AssistedImmunohistochemistryInjections, SpinalIsoenzymesMiceMice, Inbred C57BLMicroarray AnalysisPelvic PainPhosphorylationPosterior Horn CellsReal-Time Polymerase Chain ReactionRNARNA, MessengerSpinal CordTranscription, GeneticConceptsSacral spinal cordPelvic painNeurogenic cystitisProtein kinase IISpinal cordDorsal hornAssociated with urothelial lesionsChronic bladder inflammatory diseaseDevelopment of pelvic painMurine neurogenic cystitis modelCaMKII inhibitor KN-93Interstitial cystitis/painful bladder syndromeAssociated with pelvic painCa(2+)/calmodulin-dependent protein kinase IIAbductor caudalis dorsalisProgressive pelvic painPostinfection dayKinase IIInhibitor KN-93Pain-signaling pathwaysFemale C57BL/6J miceCa2+/calmodulin-dependent protein kinase IIPostinfection day 2Pelvic/perineal areaCystitis model