2015
Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Goldberg J, Fisher D, Demetri G, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut C, George S, Morgan J, Wagner A, Freeman G, Ritz J, Lezcano C, Mihm M, Canning C, Hodi F, Dranoff G. Biologic Activity of Autologous, Granulocyte–Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clinical Cancer Research 2015, 21: 3178-3186. PMID: 25805798, PMCID: PMC4506240, DOI: 10.1158/1078-0432.ccr-14-2932.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCancer VaccinesChildEnzyme-Linked Immunosorbent AssayFemaleGranulocyte-Macrophage Colony-Stimulating FactorHumansMaleMiddle AgedSarcoma, Alveolar Soft PartSarcoma, Clear CellSoft Tissue NeoplasmsYoung AdultConceptsAlveolar soft part sarcomaClear cell sarcomaGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSoft part sarcomaTissue-type plasminogen activatorMicrophthalmia transcription factorGM-CSFReplication-defective adenoviral vector encoding GM-CSFSecrete granulocyte-macrophage colony-stimulating factorCCS patientsImmune-mediated tumor destructionT-cell-mediated delayed-type hypersensitivity reactionCD8(+) T cellsAdenoviral-mediated gene transferPhase I clinical trialDelayed-type hypersensitivity reactionAutologous tumor cellsPD-ligand 1Sarcoma cellsNo tumor regressionRare mesenchymal malignancySingle-cell suspensionsTumor regressionMetastatic tumors
2013
Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain
Bojarski E, Strauss A, Fagin A, Plantinga T, Hoischen A, Veltman J, Allsop S, Granadillo V, William A, Netea M, Dimitrakoff J. Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain. PLOS ONE 2013, 8: e68118. PMID: 23861857, PMCID: PMC3704649, DOI: 10.1371/journal.pone.0068118.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphotericin BAntifungal AgentsBase SequenceChronic DiseaseClass Ib Phosphatidylinositol 3-KinaseDNA Mutational AnalysisExomeFlow CytometryGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunoglobulins, IntravenousLeukocyte CountMaleMolecular Sequence DataMutationPelvic PainReproducibility of ResultsConceptsChronic pelvic painPelvic painChronic infectionChronic purulent sinusitisLong-term treatment regimensCellular immune responsesAntifungal therapyPurulent sinusitisCandida speciesTreatment regimensProstatic fluidWork-upImmune responseSymptom improvementMissense mutationsLeukocyte functionRas-binding domainPainDebilitating symptomsInfectionMutationsSymptomsSignaling elementsRegimensRash