2017
Endocannabinoid Signaling in the Control of Social Behavior
Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid Signaling in the Control of Social Behavior. Trends In Neurosciences 2017, 40: 385-396. PMID: 28554687, PMCID: PMC5699224, DOI: 10.1016/j.tins.2017.04.005.Peer-Reviewed Original ResearchConceptsSocial behaviorEndocannabinoid signalingG-protein-coupled cannabinoid receptorsEndocannabinoid signaling systemComplex social groupsSocial anxietySocial impairmentNeural basisSocial rewardsCannabinoid receptorsNeural processesEndocannabinoidAnimal modelsEmergent insightsAnxietyRewardBehaviorSocial groupsImpairmentBrainSignaling systemAgonistsMammalian speciesReceptors
2015
Decoding Neural Circuits that Control Compulsive Sucrose Seeking
Nieh E, Matthews G, Allsop S, Presbrey K, Leppla C, Wichmann R, Neve R, Wildes C, Tye K. Decoding Neural Circuits that Control Compulsive Sucrose Seeking. Cell 2015, 160: 528-541. PMID: 25635460, PMCID: PMC4312417, DOI: 10.1016/j.cell.2015.01.003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVentral tegmental area dopamineNeural circuitsReward-predictive cuesFeeding-related behaviorsSucrose seekingReward omissionReward processingReward availabilityTegmental areaHungry miceGABA neuronsLH neuronsGABAergic projectionsDopamineRewardLearning actionsInhibitory inputsNeuronsTherapeutic interventionsSeekingCuesDisordersGABAFood consumption