2022
Analysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or Dementia
Acosta JN, Both CP, Rivier C, Szejko N, Leasure AC, Gill TM, Payabvash S, Sheth KN, Falcone GJ. Analysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or Dementia. JAMA Network Open 2022, 5: e2215328. PMID: 35622359, PMCID: PMC9142873, DOI: 10.1001/jamanetworkopen.2022.15328.Peer-Reviewed Original ResearchConceptsBrain healthBrain volumeMagnetic resonance imagingLower mean volumeLifestyle factorsCardiovascular healthLarge population-based cohort studyLife's Simple 7 (LS7) scoresPopulation-based cohort studyBrain magnetic resonance imagingMean volumeWhite matter hyperintensity volumeBrain health benefitsCommunity-dwelling personsImproved brain healthOutcomes of interestUK BiobankFinal analytical sampleAsymptomatic personsCohort studyLS7 scoreNeuroimaging markerHyperintensity volumeMAIN OUTCOMEGenetic predisposition
2016
Perihematomal Edema Expansion Rates and Patient Outcomes in Deep and Lobar Intracerebral Hemorrhage
Grunwald Z, Beslow LA, Urday S, Vashkevich A, Ayres A, Greenberg SM, Goldstein JN, Leasure A, Shi FD, Kahle KT, Battey TW, Simard JM, Rosand J, Kimberly WT, Sheth KN. Perihematomal Edema Expansion Rates and Patient Outcomes in Deep and Lobar Intracerebral Hemorrhage. Neurocritical Care 2016, 26: 205-212. PMID: 27844466, PMCID: PMC5378491, DOI: 10.1007/s12028-016-0321-3.Peer-Reviewed Original ResearchConceptsLobar intracerebral hemorrhageIntracerebral hemorrhagePoor functional outcomeDeep intracerebral hemorrhageFunctional outcomeIntraventricular hemorrhageWarfarin-related intracerebral hemorrhageSpontaneous supratentorial intracerebral hemorrhagePrimary intraventricular hemorrhageSupratentorial intracerebral hemorrhageGlasgow Coma ScaleSpontaneous intracerebral hemorrhageICH cohortSubsequent surgeryComa ScaleBaseline CTICH volumeFirst CTPatient outcomesOdds ratioInclusion criteriaPHE volumeCT scanExclusion criteriaUnadjusted regression