2018
Aberrant structural–functional coupling in adult cannabis users
Kim D, Martin A, Shin Y, Jo HJ, Cheng H, Newman SD, Sporns O, Hetrick WP, Calkins E, O'Donnell BF. Aberrant structural–functional coupling in adult cannabis users. Human Brain Mapping 2018, 40: 252-261. PMID: 30203892, PMCID: PMC6289814, DOI: 10.1002/hbm.24369.Peer-Reviewed Original ResearchConceptsStructural-functional couplingSC-FC couplingResting-state functional imagingCB usersPrimary outcome measureCannabis usersCB1 receptor densityRegion-specific disruptionCB useChronic cannabis useFunctional brain connectivityRich-club organizationOutcome measuresReceptor densitySynaptic plasticityRich-club analysisCannabis useFunctional connectivityBrain connectivityFunctional imagingAdult cannabis usersFunctional couplingBrain networksPositive associationHippocampus
2014
Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism
Ranganathan M, Sewell RA, Carbuto M, Elander J, Schnakenberg A, Radhakrishnan R, Pittman B, D’Souza D. Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism. Psychopharmacology 2014, 231: 2385-2393. PMID: 24424782, DOI: 10.1007/s00213-013-3402-4.Peer-Reviewed Original ResearchConceptsPerceptual alterationsRewarding effectsSubjective effectsAlcohol-related behaviorsΔ9-THCExecutive functionEffects of alcoholSpatial memoryMemory impairmentCounterbalanced orderAlcohol problemsFamilial vulnerabilityCannabinoid receptor functionΔ9-tetrahydrocannabinolCannabinoid Δ9-tetrahydrocannabinolFirst human studyDouble-blind conditionsCB1R functionOutcome measuresIndividualsMemoryMeasuresAlcoholismSecondary outcome measuresHuman studies