PDE4DIP in health and diseases
Mani A. PDE4DIP in health and diseases. Cellular Signalling 2022, 94: 110322. PMID: 35346821, PMCID: PMC9618167, DOI: 10.1016/j.cellsig.2022.110322.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP PhosphodiesterasesCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4HeartHeart FailureHumansSecond Messenger SystemsConceptsSecond messengerClass of enzymesCyclic AMPRecent genetic studiesSpecific cell functionsAnchoring proteinsDynamic microdomainsPathological cardiac remodelingExcitation-contraction couplingIntracellular targetingSpecific proteinsGenetic studiesCell survivalIntracellular messengerStimulating pathwaysCAMP-dependent phosphodiesteraseHeart failureDiverse classAtrial fibrillationCardiac remodelingInjury resultsPredominant isoformFunction of organsConduction velocityHeart rate