2024
Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure
Adejumo P, Thangaraj P, Dhingra L, Aminorroaya A, Zhou X, Brandt C, Xu H, Krumholz H, Khera R. Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure. JAMA Network Open 2024, 7: e2443925. PMID: 39509128, PMCID: PMC11544492, DOI: 10.1001/jamanetworkopen.2024.43925.Peer-Reviewed Original ResearchConceptsFunctional status assessmentArea under the receiver operating characteristic curveClinical documentationElectronic health record dataHF symptomsOptimal care deliveryHealth record dataAssess functional statusStatus assessmentClinical trial participationProcessing of clinical documentsFunctional status groupCare deliveryOutpatient careMain OutcomesMedical notesTrial participantsNew York Heart AssociationFunctional statusQuality improvementRecord dataHeart failureClinical notesDiagnostic studiesStatus groupsArtificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction. European Heart Journal 2024, 45: ehae666.3190. DOI: 10.1093/eurheartj/ehae666.3190.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionImmune checkpoint inhibitorsGlobal longitudinal strainLeft ventricular systolic dysfunctionNon-Hodgkin's lymphomaCardiac dysfunctionAI-ECGNegative control analysesAssociated with higher incidenceVentricular systolic dysfunctionCohort of patientsRisk stratification strategiesCheckpoint inhibitorsTrastuzumab exposureSystolic dysfunctionRisk stratificationBreast cancerRisk biomarkersSecondary outcomesLongitudinal strainStratification strategiesTrastuzumabPatientsHigher incidenceAnthracyclinesArtificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images.
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images. Circulation Cardiovascular Quality And Outcomes 2024 PMID: 39221857, DOI: 10.1161/circoutcomes.124.011504.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular systolic dysfunctionCardiac dysfunctionBreast cancerNon-Hodgkin lymphoma therapyNon-Hodgkin's lymphomaVentricular systolic dysfunctionAssociated with worse global longitudinal strainRisk stratification strategiesHigh-risk groupMonths post-treatmentPost hoc analysisElectrocardiographic (ECGTrastuzumab exposureLymphoma therapySystolic dysfunctionAI-ECGBefore treatmentRisk biomarkersLongitudinal strainLow riskStratification strategiesHigher incidencePositive screenComparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM
Khera R, Aminorroaya A, Dhingra L, Thangaraj P, Pedroso Camargos A, Bu F, Ding X, Nishimura A, Anand T, Arshad F, Blacketer C, Chai Y, Chattopadhyay S, Cook M, Dorr D, Duarte-Salles T, DuVall S, Falconer T, French T, Hanchrow E, Kaur G, Lau W, Li J, Li K, Liu Y, Lu Y, Man K, Matheny M, Mathioudakis N, McLeggon J, McLemore M, Minty E, Morales D, Nagy P, Ostropolets A, Pistillo A, Phan T, Pratt N, Reyes C, Richter L, Ross J, Ruan E, Seager S, Simon K, Viernes B, Yang J, Yin C, You S, Zhou J, Ryan P, Schuemie M, Krumholz H, Hripcsak G, Suchard M. Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM. Journal Of The American College Of Cardiology 2024, 84: 904-917. PMID: 39197980, DOI: 10.1016/j.jacc.2024.05.069.Peer-Reviewed Original ResearchConceptsGLP-1 RAsSecond-line agentsGLP-1Antihyperglycemic agentsCardiovascular diseaseMACE riskGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsEffects of SGLT2isType 2 diabetes mellitusPeptidase-4 inhibitorsAdverse cardiovascular eventsCox proportional hazards modelsRandom-effects meta-analysisCardiovascular risk reductionTarget trial emulationProportional hazards modelCorrelation between hospital rates of survival to discharge and long-term survival for in-hospital cardiac arrest: Insights from Get With The Guidelines®-Resuscitation registry
Khera R, Aminorroaya A, Kennedy K, Chan P, Investigators A, Grossestreuer A, Moskowitz A, Ornato J, Churpek M, Starks M, Girotra S, Perman S. Correlation between hospital rates of survival to discharge and long-term survival for in-hospital cardiac arrest: Insights from Get With The Guidelines®-Resuscitation registry. Resuscitation 2024, 202: 110322. PMID: 39029583, PMCID: PMC11390317, DOI: 10.1016/j.resuscitation.2024.110322.Peer-Reviewed Original ResearchRisk-standardized survival ratesIn-hospital cardiac arrestWeighted kappa coefficientResuscitation RegistryLong-term survivalSurvivors of in-hospital cardiac arrestHierarchical logistic regression modelsCardiac arrestIn-hospitalLogistic regression modelsLong-term outcomesSurvival dataKappa coefficientHospital performanceIn-hospital survivalMedicare filesMedicare beneficiariesYears of ageHospitalization ratesPost-discharge survivalHospital dischargeRate of survivalMedicareHospitalRegression modelsPerformance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study
Camargos A, Barreto S, Brant L, Ribeiro A, Dhingra L, Aminorroaya A, Bittencourt M, Figueiredo R, Khera R. Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study. Open Heart 2024, 11: e002762. PMID: 38862252, PMCID: PMC11168182, DOI: 10.1136/openhrt-2024-002762.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsELSA-BrasilRisk scoreCardiovascular diseaseCVD eventsCommunity-based cohort studyArea under the receiver operating characteristic curveCVD risk scoreELSA-Brasil studyIncident CVD eventsMiddle-income countriesAdjudicated CVD eventsCardiovascular disease riskCVD scoreCohort EquationsNational guidelinesRisk stratification scoresWhite womenAge/sex groupsCohort studyProspective cohortLMICsSex/race groupsHigher incomeRisk discriminationDevelopment and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. PMID: 39195936, DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(aReal-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysisA WEARABLE-ADAPTED ARTIFICIAL INTELLIGENCE ALGORITHM FOR HEART FAILURE PREDICTION FROM SINGLE-LEAD ELECTROCARDIOGRAMS IN A LARGE NATIONWIDE COHORT STUDY
Dhingra L, Aminorroaya A, Oikonomou E, Sangha V, Khunte A, Khera R. A WEARABLE-ADAPTED ARTIFICIAL INTELLIGENCE ALGORITHM FOR HEART FAILURE PREDICTION FROM SINGLE-LEAD ELECTROCARDIOGRAMS IN A LARGE NATIONWIDE COHORT STUDY. Journal Of The American College Of Cardiology 2024, 83: 2341. DOI: 10.1016/s0735-1097(24)04331-6.Peer-Reviewed Original ResearchCOMPARATIVE CARDIOVASCULAR EFFECTIVENESS OF ANTI-HYPERGLYCEMIC AGENTS INITIATED AS SECOND-LINE THERAPY IN TYPE 2 DIABETES: A LARGE-SCALE, MULTINATIONAL, FEDERATED TARGET TRIAL EMULATION IN THE LEGEND-T2DM STUDY
Khera R, Aminorroaya A, Dhingra L, Bu F, Camargos A, Falconer T, Zhou J, Dorr D, French T, Lau W, Lu Y, Blacketer C, Reyes C, Minty E, Li K, Man K, Ostropolets A, Nishimura A, Matheny M, Yang J, Ryan P, Y.F. W, Krumholz H, Hripcsak G, Suchard M. COMPARATIVE CARDIOVASCULAR EFFECTIVENESS OF ANTI-HYPERGLYCEMIC AGENTS INITIATED AS SECOND-LINE THERAPY IN TYPE 2 DIABETES: A LARGE-SCALE, MULTINATIONAL, FEDERATED TARGET TRIAL EMULATION IN THE LEGEND-T2DM STUDY. Journal Of The American College Of Cardiology 2024, 83: 1977. DOI: 10.1016/s0735-1097(24)03967-6.Peer-Reviewed Original ResearchTRENDS IN KNOWLEDGE OF RISK FACTOR TARGETS AMONG PATIENTS WITH DIABETES MELLITUS IN THE UNITED STATES: A NATIONALLY REPRESENTATIVE STUDY
Bansal B, Aminorroaya A, Dhingra L, Oikonomou E, Khera R. TRENDS IN KNOWLEDGE OF RISK FACTOR TARGETS AMONG PATIENTS WITH DIABETES MELLITUS IN THE UNITED STATES: A NATIONALLY REPRESENTATIVE STUDY. Journal Of The American College Of Cardiology 2024, 83: 1882. DOI: 10.1016/s0735-1097(24)03872-5.Peer-Reviewed Original ResearchWEARABLE DEVICE USE PATTERNS AMONG THOSE WITH CARDIOVASCULAR RISK IN ALL OF US RESEARCH PROGRAM: AN EVALUATION AGAINST A NATIONALLY REPRESENTATIVE DATABASE
Feliciano K, Aminorroaya A, Dhingra L, Thangaraj P, Adejumo P, Khera R. WEARABLE DEVICE USE PATTERNS AMONG THOSE WITH CARDIOVASCULAR RISK IN ALL OF US RESEARCH PROGRAM: AN EVALUATION AGAINST A NATIONALLY REPRESENTATIVE DATABASE. Journal Of The American College Of Cardiology 2024, 83: 2045. DOI: 10.1016/s0735-1097(24)04035-x.Peer-Reviewed Original ResearchA NOVEL DEEP LEARNING APPROACH FOR AUTOMATED EXTRACTION OF FUNCTIONAL STATUS AND NEW YORK HEART ASSOCIATION CLASS FOR HEART FAILURE PATIENTS DURING OUTPATIENT ENCOUNTERS
Adejumo P, Dhingra L, Aminorroaya A, Khera R. A NOVEL DEEP LEARNING APPROACH FOR AUTOMATED EXTRACTION OF FUNCTIONAL STATUS AND NEW YORK HEART ASSOCIATION CLASS FOR HEART FAILURE PATIENTS DURING OUTPATIENT ENCOUNTERS. Journal Of The American College Of Cardiology 2024, 83: 313. DOI: 10.1016/s0735-1097(24)02303-9.Peer-Reviewed Original ResearchMULTINATIONAL REAL-WORLD EVALUATION OF A MACHINE LEARNING-DERIVED TOOL FOR ANATOMICAL VERSUS FUNCTIONAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE
Oikonomou E, Aminorroaya A, Dhingra L, Khera R. MULTINATIONAL REAL-WORLD EVALUATION OF A MACHINE LEARNING-DERIVED TOOL FOR ANATOMICAL VERSUS FUNCTIONAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2024, 83: 1357. DOI: 10.1016/s0735-1097(24)03347-3.Peer-Reviewed Original ResearchCORRELATION BETWEEN HOSPITAL RATES OF SURVIVAL TO DISCHARGE AND LONG-TERM SURVIVAL FOR IN-HOSPITAL CARDIAC ARREST: INSIGHTS FROM GET WITH THE GUIDELINES®RESUSCITATION
Aminorroaya A, Chan P, Kennedy K, Khera R. CORRELATION BETWEEN HOSPITAL RATES OF SURVIVAL TO DISCHARGE AND LONG-TERM SURVIVAL FOR IN-HOSPITAL CARDIAC ARREST: INSIGHTS FROM GET WITH THE GUIDELINES®RESUSCITATION. Journal Of The American College Of Cardiology 2024, 83: 2557. DOI: 10.1016/s0735-1097(24)04547-9.Peer-Reviewed Original ResearchUSING PHOTOS OF ELECTROCARDIOGRAMS AS A BIOMARKER FOR CARDIOVASCULAR RISK - A MULTINATIONAL ASSESSMENT OF A NOVEL ARTIFICIAL INTELLIGENCE APPROACH
Sangha V, Dhingra L, Aminorroaya A, Khera R. USING PHOTOS OF ELECTROCARDIOGRAMS AS A BIOMARKER FOR CARDIOVASCULAR RISK - A MULTINATIONAL ASSESSMENT OF A NOVEL ARTIFICIAL INTELLIGENCE APPROACH. Journal Of The American College Of Cardiology 2024, 83: 2443. DOI: 10.1016/s0735-1097(24)04433-4.Peer-Reviewed Original ResearchHEART FAILURE RISK PREDICTION USING ARTIFICIAL INTELLIGENCE ON ECG PHOTOS IN LARGE CONTEMPORARY COHORT
Dhingra L, Sangha V, Aminorroaya A, Camargos A, Oikonomou E, Khera R. HEART FAILURE RISK PREDICTION USING ARTIFICIAL INTELLIGENCE ON ECG PHOTOS IN LARGE CONTEMPORARY COHORT. Journal Of The American College Of Cardiology 2024, 83: 277. DOI: 10.1016/s0735-1097(24)02267-8.Peer-Reviewed Original ResearchBurden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the GBD Study 2019
Aminorroaya A, Moghaddam S, Tavolinejad H, Aryan Z, Heidari B, Ebrahimi H, Naderian M, Shobeiri P, Ghanbari A, Rezaei N, Malekpour M, Haghshenas R, Rezaei N, Larijani B, Farzadfar F. Burden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the GBD Study 2019. Journal Of The American Heart Association 2024, 13: e030165. PMID: 37956220, PMCID: PMC10926818, DOI: 10.1161/jaha.123.030165.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsBurden of ischemic heart diseaseDisability-adjusted life year ratesRates of ischemic heart diseaseIschemic heart diseaseRisk factorsMortality of ischemic heart diseaseEpidemiology of ischemic heart diseaseIschemic heart disease burdenHigh low-density lipoprotein cholesterolDietary risk factorsLost disability-adjusted life yearsYears of lifeHeart diseaseGBD studyPremature mortalityLow-density lipoprotein cholesterolSystolic blood pressureHighest burdenMetabolic riskBehavioral risksLife yearsPremature deathContemporary epidemiologyLipoprotein cholesterol
2023
Multinational patterns of second line antihyperglycaemic drug initiation across cardiovascular risk groups: federated pharmacoepidemiological evaluation in LEGEND-T2DM
Khera R, Dhingra L, Aminorroaya A, Li K, Zhou J, Arshad F, Blacketer C, Bowring M, Bu F, Cook M, Dorr D, Duarte-Salles T, DuVall S, Falconer T, French T, Hanchrow E, Horban S, Lau W, Li J, Liu Y, Lu Y, Man K, Matheny M, Mathioudakis N, McLemore M, Minty E, Morales D, Nagy P, Nishimura A, Ostropolets A, Pistillo A, Posada J, Pratt N, Reyes C, Ross J, Seager S, Shah N, Simon K, Wan E, Yang J, Yin C, You S, Schuemie M, Ryan P, Hripcsak G, Krumholz H, Suchard M. Multinational patterns of second line antihyperglycaemic drug initiation across cardiovascular risk groups: federated pharmacoepidemiological evaluation in LEGEND-T2DM. BMJ Medicine 2023, 2: e000651. PMID: 37829182, PMCID: PMC10565313, DOI: 10.1136/bmjmed-2023-000651.Peer-Reviewed Original ResearchType 2 diabetes mellitusSecond-line treatmentCardiovascular risk groupsDiabetes mellitusCardiovascular diseaseAntihyperglycaemic drugsLine treatmentRisk groupsObservational Health Data SciencesGlucagon-like peptide-1 receptor agonistsElectronic health recordsSodium-glucose cotransporter 2 inhibitorsCalendar year trendsPeptide-1 receptor agonistsUS databaseOutcomes of patientsCotransporter 2 inhibitorsAdministrative claims databaseSecond-line drugsHealth recordsSodium-glucose cotransporter-2 inhibitorsMedication useMetformin monotherapyGuideline recommendationsOutcome measuresRisk of incident cardiovascular diseases at national and subnational levels in Iran from 2000 to 2016 and projection through 2030: Insights from Iran STEPS surveys
Ebrahimi H, Masinaei M, Aminorroaya A, Aryan Z, Mehdipour P, Rostam-Abadi Y, Ahmadi N, Moghaddam S, Pishgar F, Ghanbari A, Rezaei N, Takian A, Farzadfar F. Risk of incident cardiovascular diseases at national and subnational levels in Iran from 2000 to 2016 and projection through 2030: Insights from Iran STEPS surveys. PLOS ONE 2023, 18: e0290006. PMID: 37611004, PMCID: PMC10446220, DOI: 10.1371/journal.pone.0290006.Peer-Reviewed Original ResearchConceptsCardiovascular disease riskRisk of cardiovascular diseaseNon-communicable disease risk factor surveillanceCardiovascular diseaseCVD riskWorld Health OrganizationRisk of incident cardiovascular diseaseRisk factor surveillanceFramingham 10-year CVD riskAdult Iranian populationIncident cardiovascular diseaseRisk factor modificationCardiovascular disease risk stratificationEvidence-based decisionsFramingham modelHealth policyNationally representative datasetFactor modificationRisk estimation modelIranian populationHealth OrganizationFraminghamSurvey's backgroundRiskSubnational level