2017
Evolution of Gene Expression in the Uterine Cervix related to Steroid Signaling: Conserved features in the regulation of cervical ripening
Wagner GP, Nnamani MC, Chavan AR, Maziarz J, Protopapas S, Condon J, Romero R. Evolution of Gene Expression in the Uterine Cervix related to Steroid Signaling: Conserved features in the regulation of cervical ripening. Scientific Reports 2017, 7: 4439. PMID: 28667298, PMCID: PMC5493687, DOI: 10.1038/s41598-017-04759-6.Peer-Reviewed Original ResearchConceptsGene expressionComparative transcriptomic studyEutherian mammalsPlacental mammalsCervical ripeningTranscriptomic studiesEutherian speciesSteroid signalingUterine cervixChange expressionTiming of parturitionMammalsPremature cervical ripeningFunctional progesterone withdrawalDecreased expressionMaintenance of pregnancyExpressionSpeciesRipeningPutative mechanismsPreterm birthProgesterone withdrawalProgesterone receptorMouse cervixCervixSingle-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface
Pavličev M, Wagner GP, Chavan AR, Owens K, Maziarz J, Dunn-Fletcher C, Kallapur SG, Muglia L, Jones H. Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Genome Research 2017, 27: 349-361. PMID: 28174237, PMCID: PMC5340963, DOI: 10.1101/gr.207597.116.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomicsG protein-coupled receptorsCell communication networksGene expression profilesReceptor-ligand pairsCell type identificationOrganismal functionInteraction hubTrophoblast cellsGene expressionExpression profilesEndometrial stromal fibroblastsSpecific expressionCell typesInteractomeTranscriptomicsRich resourceCell interactionsPlacental trophoblast cellsDecidual cellsImmune signalsStromal cellsGrowth factorStromal fibroblastsEndometrial stromal cells
2016
The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts
Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Birt A, Emera D, Lynch VJ, Ott TL, Pavlicev M, Wagner GP. The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts. Genome Biology And Evolution 2016, 8: 2459-2473. PMID: 27401177, PMCID: PMC5010902, DOI: 10.1093/gbe/evw168.Peer-Reviewed Original ResearchConceptsEndometrial stromal fibroblastsGene expression changesTherian speciesEutherian lineagesTranscriptome compositionBovine lineageStem lineageNatural selectionStromal fibroblastsTherian mammalsEutherian mammalsKey genesLoss of expressionTranscriptomic evolutionGene expressionExpression changesLatter cell typeGenesLineagesCell typesCell type presentMammalsMammalian pregnancyExpressionTissue invasion
2012
Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity
Fraser H, Levy S, Chavan A, Shah H, Perez J, Zhou Y, Siegal M, Sinha H. Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Research 2012, 22: 1930-1939. PMID: 22645260, PMCID: PMC3460188, DOI: 10.1101/gr.134080.111.Peer-Reviewed Original ResearchConceptsSingle-allele knockoutEvolution of pathogenicityDiverse yeast strainsCis-regulatory mutationsMode of evolutionWild-type progenitorPathogenic yeastsGene expression levelsPolygenic adaptationSelective sweepsPathogenic lifestyleNew genesMorphological traitsYeast SaccharomycesMammalian hostsMicrobial pathogenicityHorizontal transferStandard laboratory conditionsGene expressionCompensatory mutationsYeast pathogenicityYeast strainGrowth advantagePleiotropic effectsGenetic variants