2023
Tissue Biology: In Search of a New Paradigm
Adler M, Chavan A, Medzhitov R. Tissue Biology: In Search of a New Paradigm. Annual Review Of Cell And Developmental Biology 2023, 39: 67-89. PMID: 37607470, DOI: 10.1146/annurev-cellbio-120420-113830.Peer-Reviewed Original Research
2020
Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals
Chavan AR, Griffith OW, Stadtmauer D, Maziarz J, Pavlicev M, Fishman R, Koren L, Romero R, Wagner GP. Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals. Molecular Biology And Evolution 2020, 38: 1060-1074. PMID: 33185661, PMCID: PMC7947829, DOI: 10.1093/molbev/msaa274.Peer-Reviewed Original ResearchConceptsEutherian mammalsEutherian lineagesDecidual stromal cellsNovel cell typesStromal cellsInflammatory responseStem lineageEutherian pregnancyCommon ancestorEvolutionary mechanismsExtended gestationMost marsupialsEmbryo attachmentEmbryo implantationMarsupialsLineagesCell typesMammalsMechanistic understandingEutheriansHelper T cellsFetal-maternal interfaceMammalian pregnancyMaternal tissuesNeutrophil recruitment
2018
The mammalian decidual cell evolved from a cellular stress response
Erkenbrack EM, Maziarz JD, Griffith OW, Liang C, Chavan AR, Nnamani MC, Wagner GP. The mammalian decidual cell evolved from a cellular stress response. PLOS Biology 2018, 16: e2005594. PMID: 30142145, PMCID: PMC6108454, DOI: 10.1371/journal.pbio.2005594.Peer-Reviewed Original ResearchConceptsCellular stress responseNovel cell typesStress responseEndometrial stromal fibroblastsCell typesCell type diversityDecidual stromal cellsCore regulatory genesOxidative stress responseDecidual cell typesEvolutionary noveltyPrecursor cell typesEffector genesRegulatory genesEutherian mammalsTranscription factorsOpossum Monodelphis domesticaOrganismal structureType diversityMolecular mechanismsAnimal speciesMonodelphis domesticaGenesStromal cellsSpecies
2017
Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface
Pavličev M, Wagner GP, Chavan AR, Owens K, Maziarz J, Dunn-Fletcher C, Kallapur SG, Muglia L, Jones H. Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Genome Research 2017, 27: 349-361. PMID: 28174237, PMCID: PMC5340963, DOI: 10.1101/gr.207597.116.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomicsG protein-coupled receptorsCell communication networksGene expression profilesReceptor-ligand pairsCell type identificationOrganismal functionInteraction hubTrophoblast cellsGene expressionExpression profilesEndometrial stromal fibroblastsSpecific expressionCell typesInteractomeTranscriptomicsRich resourceCell interactionsPlacental trophoblast cellsDecidual cellsImmune signalsStromal cellsGrowth factorStromal fibroblastsEndometrial stromal cells
2016
The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts
Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Birt A, Emera D, Lynch VJ, Ott TL, Pavlicev M, Wagner GP. The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts. Genome Biology And Evolution 2016, 8: 2459-2473. PMID: 27401177, PMCID: PMC5010902, DOI: 10.1093/gbe/evw168.Peer-Reviewed Original ResearchConceptsEndometrial stromal fibroblastsGene expression changesTherian speciesEutherian lineagesTranscriptome compositionBovine lineageStem lineageNatural selectionStromal fibroblastsTherian mammalsEutherian mammalsKey genesLoss of expressionTranscriptomic evolutionGene expressionExpression changesLatter cell typeGenesLineagesCell typesCell type presentMammalsMammalian pregnancyExpressionTissue invasion