1991
Inherited Hepatic Enzyme Defects as Candidates for Liver-Directed Gene Therapy
Horwich A. Inherited Hepatic Enzyme Defects as Candidates for Liver-Directed Gene Therapy. Current Topics In Microbiology And Immunology 1991, 168: 185-200. PMID: 1893777, DOI: 10.1007/978-3-642-76015-0_9.Peer-Reviewed Original Research
1990
THE EFFECTS OF EARLY TREATMENT OF HEREDITARY TYROSINEMIA TYPE I IN INFANCY BY ORTHOTOPIC LIVER TRANSPLANTATION
Flye M, RIELY C, HAINLINE B, SASSA S, GUSBERG R, BLAKEMORE K, BARWICK K, HORWICH A. THE EFFECTS OF EARLY TREATMENT OF HEREDITARY TYROSINEMIA TYPE I IN INFANCY BY ORTHOTOPIC LIVER TRANSPLANTATION. Transplantation 1990, 49: 916-921. PMID: 2336709, DOI: 10.1097/00007890-199005000-00017.Peer-Reviewed Original ResearchConceptsOrthotopic liver transplantationLiver transplantationMedical therapyHereditary tyrosinemiaEarly liver transplantationMinimal perioperative complicationsWeeks of ageTyrosinemia type IPerioperative complicationsRapid institutionPoor prognosisNormal dietEarly treatmentMetabolic disordersTransplantationPrompt clearanceAbnormal metabolitesHydrolase deficiencyInfantsMental alertnessProgressive growthTherapyType ITyrosinemiaBiochemical responses