1997
GroEL‐Mediated protein folding
Fenton W, Horwich A. GroEL‐Mediated protein folding. Protein Science 1997, 6: 743-760. PMID: 9098884, PMCID: PMC2144759, DOI: 10.1002/pro.5560060401.Peer-Reviewed Original ResearchConceptsGroEL-GroESNonnative polypeptidesSubstrate proteinsATP bindingProtein foldingHomologous proteinsNonnative formsPrimary structureConformational changesGroELTernary complexPolypeptideAssociation 5FoldingProteinBindingChaperonesGroESConformationEnergy landscapeRole of hydrophobicityPathway 3RolePathwayComplex C.
1994
Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell
Craig E, Weissman J, Horwich A. Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell. Cell 1994, 78: 365-372. PMID: 7914834, DOI: 10.1016/0092-8674(94)90416-2.Peer-Reviewed Original ResearchGroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms
Weissman J, Kashi Y, Fenton W, Horwich A. GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms. Cell 1994, 78: 693-702. PMID: 7915201, DOI: 10.1016/0092-8674(94)90533-9.Peer-Reviewed Original ResearchConceptsCochaperonin GroESMultiple roundsGroEL functionChaperonin GroELKinetic partitioningMutant formsNonnative conformationsNonnative formsGroELAddition of ATPGroEL moleculeTryptophan fluorescenceFolding reactionDouble-ring structureUnfolded statePolypeptideDiverse setGroESProteolysisProteinATPBindingFateConformationComplexes
1991
Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate
Martin J, Langer T, Boteva R, Schramel A, Horwich A, Hartl F. Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate. Nature 1991, 352: 36-42. PMID: 1676490, DOI: 10.1038/352036a0.Peer-Reviewed Original ResearchConceptsChaperonin-mediated proteinMolten globule-like intermediateMolten globule stateGroEL proteinProtein monomersMonomeric enzymeProtein structureTertiary structureATP moleculesGlobule stateGeneral mechanismMg-ATPGroESGroELFoldingProteinActive processPolypeptideEnzymeChain foldingConformationVivo