2017
Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens
Parchure A, Vyas N, Mayor S. Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens. Trends In Cell Biology 2017, 28: 157-170. PMID: 29132729, PMCID: PMC6941938, DOI: 10.1016/j.tcb.2017.10.003.Peer-Reviewed Original ResearchGetting mRNA-Containing Ribonucleoprotein Granules Out of a Nuclear Back Door
Parchure A, Munson M, Budnik V. Getting mRNA-Containing Ribonucleoprotein Granules Out of a Nuclear Back Door. Neuron 2017, 96: 604-615. PMID: 29096075, DOI: 10.1016/j.neuron.2017.10.020.Peer-Reviewed Original ResearchConceptsNuclear pore complexNE buddingNuclear envelope buddingProtein synthesis machineryLocalization of RNAEndogenous cellular processesNuclear escapeLarge RNPsPore complexSynthesis machineryNuclear assemblyTransport granulesCellular processesNuclear exportSynaptic plasticityProtein aggregatesBuddingViral capsidRecent findingsSynthetic activitySynaptic sitesRecent studiesPlasticityDrosophilaRibonucleoprotein
2015
Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion
Parchure A, Vyas N, Ferguson C, Parton R, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Molecular Biology Of The Cell 2015, 26: 4700-4717. PMID: 26490120, PMCID: PMC4678025, DOI: 10.1091/mbc.e15-09-0671.Peer-Reviewed Original ResearchConceptsLong-range signalingMultivesicular bodiesEndocytic deliveryDrosophila wing imaginal discWing imaginal discsESCRT proteinsLipidated proteinsSecreted morphogenImaginal discsNanoscale organizationExovesiclesHedgehogSignalingProteinOligomerizationHhDependent processesESCRTSelective effectTurn actMorphogensEndocytosisAqueous milieuSecretionComplexes