The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo
Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. Journal Of Biological Chemistry 2018, 293: 17317-17335. PMID: 30242130, PMCID: PMC6231134, DOI: 10.1074/jbc.ra118.003908.Peer-Reviewed Original ResearchConceptsActin-binding regionZO-2Apical surfaceF-actinOrganization of microvilliCortical F-actinZonula occludens-1F-actin disruptionZO-1 interactionCultured epithelial cellsMembrane trafficGUK domainApical specializationsApical epithelial surfacePDZ1 domainPolarized epitheliumEpithelial organizationActomyosin contractionApical structuresProtein ZO-1Tissue organizationActomyosin functionDevelopmental stagesProtein zonula occludens-1Direct interactionEnvironmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses
Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Ahmed K, Qureshi S, Moore SR, Turner J, Ali SA. Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1577-1584. PMID: 29611507, PMCID: PMC6086170, DOI: 10.4269/ajtmh.17-0306.Peer-Reviewed Original ResearchConceptsCeliac diseaseUnderwent upper endoscopyB cell aggregatesHost disease patientsUse therapeutic foodAge-matched specimensResource-poor countriesT lymphocytosisIntraepithelial lymphocytosisDuodenal biopsiesUpper endoscopyVillous atrophyLymphocytic activationEnvironmental enteropathyImmunological featuresDisease patientsMalnourished infantsHealthy controlsNutritional supplementationNutrition interventionsT lymphocytesLamina propriaInsufficient responseTherapeutic foodBirth cohort