2019
Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease
Ong MLDM, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. Laboratory Investigation 2019, 100: 483-490. PMID: 31605016, PMCID: PMC7047618, DOI: 10.1038/s41374-019-0324-8.Peer-Reviewed Original ResearchConceptsCommon variable immunodeficiencyInflammatory bowel diseaseClaudin-15 expressionCeliac diseaseMalabsorptive diseaseClaudin-2 expressionClaudin-2Claudin-15Host diseaseDuodenal biopsiesBowel diseaseVariable immunodeficiencyHealthy childrenHealthy controlsNutrient cotransportPostnatal developmentGVHDDiseaseSpecific claudinsQuantitative immunofluorescence microscopyAdultsChildrenImmunofluorescence microscopyDifferential regulationExpression changes
2018
Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses
Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Ahmed K, Qureshi S, Moore SR, Turner J, Ali SA. Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1577-1584. PMID: 29611507, PMCID: PMC6086170, DOI: 10.4269/ajtmh.17-0306.Peer-Reviewed Original ResearchConceptsCeliac diseaseUnderwent upper endoscopyB cell aggregatesHost disease patientsUse therapeutic foodAge-matched specimensResource-poor countriesT lymphocytosisIntraepithelial lymphocytosisDuodenal biopsiesUpper endoscopyVillous atrophyLymphocytic activationEnvironmental enteropathyImmunological featuresDisease patientsMalnourished infantsHealthy controlsNutritional supplementationNutrition interventionsT lymphocytesLamina propriaInsufficient responseTherapeutic foodBirth cohort
2017
Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia
Amadi B, Besa E, Zyambo K, Kaonga P, Louis-Auguste J, Chandwe K, Tarr PI, Denno DM, Nataro JP, Faubion W, Sailer A, Yeruva S, Brantner T, Murray J, Prendergast AJ, Turner JR, Kelly P. Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia. EBioMedicine 2017, 22: 191-199. PMID: 28750860, PMCID: PMC5552244, DOI: 10.1016/j.ebiom.2017.07.017.Peer-Reviewed Original ResearchConceptsSevere acute malnutritionHealthy childrenVillus heightIntestinal barrier failureImpaired barrier functionBacterial translocationImmune dysregulationIntestinal damageIntestinal secretionPersistent diarrheaAcute malnutritionAutoantibody generationHistological lesionsMalnourished childrenTranslocation markersCrypt depthNormal rangeHealthy adultsIgG concentrationsClaudin-4Adult controlsAnalysis of markersBarrier functionMalnutritionEpithelial surface