2019
Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease
Ong MLDM, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. Laboratory Investigation 2019, 100: 483-490. PMID: 31605016, PMCID: PMC7047618, DOI: 10.1038/s41374-019-0324-8.Peer-Reviewed Original ResearchConceptsCommon variable immunodeficiencyInflammatory bowel diseaseClaudin-15 expressionCeliac diseaseMalabsorptive diseaseClaudin-2 expressionClaudin-2Claudin-15Host diseaseDuodenal biopsiesBowel diseaseVariable immunodeficiencyHealthy childrenHealthy controlsNutrient cotransportPostnatal developmentGVHDDiseaseSpecific claudinsQuantitative immunofluorescence microscopyAdultsChildrenImmunofluorescence microscopyDifferential regulationExpression changes
2017
Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia
Amadi B, Besa E, Zyambo K, Kaonga P, Louis-Auguste J, Chandwe K, Tarr PI, Denno DM, Nataro JP, Faubion W, Sailer A, Yeruva S, Brantner T, Murray J, Prendergast AJ, Turner JR, Kelly P. Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia. EBioMedicine 2017, 22: 191-199. PMID: 28750860, PMCID: PMC5552244, DOI: 10.1016/j.ebiom.2017.07.017.Peer-Reviewed Original ResearchConceptsSevere acute malnutritionHealthy childrenVillus heightIntestinal barrier failureImpaired barrier functionBacterial translocationImmune dysregulationIntestinal damageIntestinal secretionPersistent diarrheaAcute malnutritionAutoantibody generationHistological lesionsMalnourished childrenTranslocation markersCrypt depthNormal rangeHealthy adultsIgG concentrationsClaudin-4Adult controlsAnalysis of markersBarrier functionMalnutritionEpithelial surface