Featured Publications
Abnormal transporter and tight junction protein expression in environmental enteric dysfunction
Abtahi S, Sailer A, Sadiq K, Iqbal N, Ahmed K, Kabir F, Ali S, Turner J. Abnormal transporter and tight junction protein expression in environmental enteric dysfunction. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r5615.Peer-Reviewed Original ResearchEnvironmental enteric dysfunctionClaudin-4 expressionTight junction proteinsEnteric dysfunctionBarrier dysfunctionTight junction protein expressionJunction proteinsJunction protein expressionCeliac disease patientsExpression of occludinAbsorption of glucoseNon-celiac patientsFurther studiesTight junction barrier functionEED patientsIntraepithelial lymphocytosisDuodenal biopsiesVillous atrophyDisease patientsIntestinal permeabilityHealthy controlsOccludin expressionIrreversible deficitsMalabsorptionBarrier loss
2019
Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease
Ong MLDM, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. Laboratory Investigation 2019, 100: 483-490. PMID: 31605016, PMCID: PMC7047618, DOI: 10.1038/s41374-019-0324-8.Peer-Reviewed Original ResearchConceptsCommon variable immunodeficiencyInflammatory bowel diseaseClaudin-15 expressionCeliac diseaseMalabsorptive diseaseClaudin-2 expressionClaudin-2Claudin-15Host diseaseDuodenal biopsiesBowel diseaseVariable immunodeficiencyHealthy childrenHealthy controlsNutrient cotransportPostnatal developmentGVHDDiseaseSpecific claudinsQuantitative immunofluorescence microscopyAdultsChildrenImmunofluorescence microscopyDifferential regulationExpression changes
2018
Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses
Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Ahmed K, Qureshi S, Moore SR, Turner J, Ali SA. Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1577-1584. PMID: 29611507, PMCID: PMC6086170, DOI: 10.4269/ajtmh.17-0306.Peer-Reviewed Original ResearchConceptsCeliac diseaseUnderwent upper endoscopyB cell aggregatesHost disease patientsUse therapeutic foodAge-matched specimensResource-poor countriesT lymphocytosisIntraepithelial lymphocytosisDuodenal biopsiesUpper endoscopyVillous atrophyLymphocytic activationEnvironmental enteropathyImmunological featuresDisease patientsMalnourished infantsHealthy controlsNutritional supplementationNutrition interventionsT lymphocytesLamina propriaInsufficient responseTherapeutic foodBirth cohort