The Notch ligand Delta‐like 4 (Dll4) negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, del Toro R, le Noble F, Benedito R, Breant C, Duarte A, Eichmann A. The Notch ligand Delta‐like 4 (Dll4) negatively regulates endothelial tip cell formation and vessel branching. The FASEB Journal 2007, 21: a15-a15. DOI: 10.1096/fasebj.21.5.a15-a.Peer-Reviewed Original ResearchTip cell formationEndothelial tip cell formationTip cellsCell formationNovel negative regulatorCell marker genesEndothelial tip cellsLigand Delta-like 4Severe vascular abnormalitiesVessel branchingDelta-like 4Notch ligand Delta-like 4Embryonic lethalExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNotch signalingNegative regulatorAngiogenic sproutingVEGF stimulationVEGF receptor 2Filopodia extensionGenetic backgroundThe Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 3225-3230. PMID: 17296941, PMCID: PMC1805603, DOI: 10.1073/pnas.0611177104.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesAnimalsCalcium-Binding ProteinsEndothelium, VascularGamma-Aminobutyric AcidImmunohistochemistryIn Situ HybridizationIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Mutant StrainsReceptors, Vascular Endothelial Growth FactorRetinal VesselsSignal TransductionTriglyceridesVascular Endothelial Growth Factor AConceptsTip cell formationEndothelial tip cell formationTip cellsNotch ligand DeltaCell formationCell marker genesEndothelial tip cellsVessel branchingLigand DeltaExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNegative regulatorAngiogenic sproutingVEGF receptor 2VEGF stimulationFilopodia extensionGamma-secretase inhibitorsGrowth factor VEGFVascular sproutingPharmacological inhibitionDll4Heterozygous deletion