2011
Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B
Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A. Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B. Developmental Cell 2011, 20: 33-46. PMID: 21238923, DOI: 10.1016/j.devcel.2010.12.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BlockingBlood VesselsCapillary PermeabilityEnzyme ActivationHumansLigandsMiceModels, BiologicalNeovascularization, PathologicNerve Tissue ProteinsNetrin ReceptorsProtein BindingReceptors, Cell SurfaceReceptors, ImmunologicRetinal VesselsSignal TransductionSrc-Family KinasesSus scrofaVascular Endothelial Growth Factor AConceptsProtein-protein interaction screenVascular endothelial growth factorFunction-blocking monoclonal antibodiesInteraction screenNovel functionGuidance receptorsExtracellular domainNetrin receptorsReceptor familyVessel integrityReceptor interactionInhibits angiogenesisRobo4Unexpected interactionsGrowth factorEndothelial cellsUNC5BVascular integrityEndothelial growth factorAngiogenesisIncreases angiogenesisReceptorsMonoclonal antibodiesIntegrityProtein
2008
Regulation of blood vessel patterning and branching
Eichmann A. Regulation of blood vessel patterning and branching. The FASEB Journal 2008, 22: 391.2-391.2. DOI: 10.1096/fasebj.22.1_supplement.391.2.Peer-Reviewed Original ResearchMatrix-bound vascular endothelial growth factorVertebrate vascular systemBlood vessel patterningAxon guidance cue netrin-1Endothelial tip cellsAxonal growth conesVessel morphogenesisVessel patterningGuidance cue netrin-1Tip cellsSpecialized endothelial cellsEndothelial cellsNegative regulatorPathological angiogenesisGrowth conesUNC5B receptorDelta-like4Vessel branchingGrowth factorBranched networkVascular endothelial growth factorNetrin-1Endothelial growth factorVascular systemCells
2007
Molecular mechanisms controling vessel branching and morphogenesis
Eichmann A. Molecular mechanisms controling vessel branching and morphogenesis. The FASEB Journal 2007, 21: a197-a197. DOI: 10.1096/fasebj.21.5.a197-b.Peer-Reviewed Original ResearchMatrix-bound vascular endothelial growth factorVertebrate vascular systemAxon guidance cue netrin-1Endothelial tip cellsVessel branchingAxonal growth conesVessel morphogenesisGuidance cue netrin-1Tip cellsSpecialized endothelial cellsEndothelial cellsNegative regulatorMolecular mechanismsPathological angiogenesisGrowth conesUNC5B receptorMorphogenesisDelta-like4Growth factorBranched networkVascular endothelial growth factorNetrin-1Vascular systemEndothelial growth factorCells
1999
Endothelial cell precursors in the avian embryo.
Eichmann A, Corbel C. Endothelial cell precursors in the avian embryo. Current Research In Translational Medicine 1999, 47: 307-13. PMID: 10372398.Peer-Reviewed Original ResearchConceptsAvian embryosEndothelial cellsEndothelial cell precursorsGastrulation stagePosterior mesodermGrowth factorDevelopmental biologySpecific growth factorsVascular endothelial growth factorOnly endothelial cellsMolecular mechanismsHematopoietic cellsEmbryosCell precursorsCulture experimentsSignificant insightsEndothelial growth factorVascular systemCellsVEGFR2-positive cellsMesodermMammalsAngioblastsReceptorsBiology