2024
Abstract 971: Validation of a tumor-naïve circulating tumor DNA (ctDNA) response monitoring panel in advanced non-small cell lung cancer (aNSCLC)
Chiang A, Madison R, Huang Y, Fine A, Jin D, Oxnard G, Hughes J, Assaf Z, Cao Y, Antic V, Gjoerup O, Young A, Fabrizio D, Lakhanpal S, Zuniga R, Schulze K, Pasquina L. Abstract 971: Validation of a tumor-naïve circulating tumor DNA (ctDNA) response monitoring panel in advanced non-small cell lung cancer (aNSCLC). Cancer Research 2024, 84: 971-971. DOI: 10.1158/1538-7445.am2024-971.Peer-Reviewed Original ResearchAdvanced non-small cell lung cancerPeripheral blood mononuclear cellsNon-small cell lung cancerRisk of progressionCell lung cancerClonal hematopoiesisTumor fractionGenomic alterationsTumor signalAmerican Association for Cancer Research annual meetingsLung cancerHazard ratioPatient's risk of progressionFrequency of genomic alterationsAssociated with favorable outcomesMolecular responseWeeks of TxProgression free survivalUnivariate Cox proportional hazards regressionCox proportional hazards regressionBlood mononuclear cellsConfidence intervalsVariant allele frequencyCombination of aneuploidyProportional hazards regression
2023
Using real world practice patterns to identify clinical equipoise in cancer treatment: Advanced non-small cell lung cancer as an exemplar.
Li Y, Yang S, Chiang A, Gross C, Wang S. Using real world practice patterns to identify clinical equipoise in cancer treatment: Advanced non-small cell lung cancer as an exemplar. JCO Oncology Practice 2023, 19: 539-539. DOI: 10.1200/op.2023.19.11_suppl.539.Peer-Reviewed Original ResearchNon-small cell lung cancerAdvanced non-small cell lung cancerPD-L1 1First-line therapyCell lung cancerTreatment patternsECOG 2PD-L1Clinical equipoiseLung cancerHHI scoresEastern Cooperative Oncology Group performance scoreFirst-line treatment regimensReal-world practice patternsALK/EGFRActionable gene alterationsStandard of careConfidence intervalsGroup performance scoreComparative effectiveness researchECOG statusOverall cohortPerformance statusECOG scoreTreatment regimens