2012
Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
Park J, Wrzesinski SH, Stern E, Look M, Criscione J, Ragheb R, Jay SM, Demento SL, Agawu A, Licona Limon P, Ferrandino AF, Gonzalez D, Habermann A, Flavell RA, Fahmy TM. Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nature Materials 2012, 11: 895-905. PMID: 22797827, PMCID: PMC3601683, DOI: 10.1038/nmat3355.Peer-Reviewed Original ResearchConceptsInterleukin-2TGF-β inhibitorTumor microenvironmentImmune responseLocal tumor immune responseMultiple immunologic mechanismsT cell infiltrationNatural killer cellsTumor immune responseAdaptive immune responsesTumor-bearing miceImmunotherapy resultsConventional immunotherapyImmunologic mechanismsKiller cellsTumor immunotherapyMetastatic melanomaConventional cytokinesProtein cytokinesHigh dosesTumor growthGrowth factorMolecular inhibitorsCombination deliveryImmunotherapy
2010
Cellular choreography in the germinal center: new visions from in vivo imaging
Hauser AE, Kerfoot SM, Haberman AM. Cellular choreography in the germinal center: new visions from in vivo imaging. Seminars In Immunopathology 2010, 32: 239-255. PMID: 20614218, PMCID: PMC3659422, DOI: 10.1007/s00281-010-0214-z.Peer-Reviewed Original Research
2000
A B-cell receptor-specific selection step governs immature to mature B cell differentiation
Levine M, Haberman A, Sant'Angelo D, Hannum L, Cancro M, Janeway C, Shlomchik M. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 2743-2748. PMID: 10688906, PMCID: PMC16000, DOI: 10.1073/pnas.050552997.Peer-Reviewed Original ResearchConceptsImmature B cellsMature B cellsB cell receptor repertoirePositive selection eventsB cell differentiationReceptor repertoireSelection eventsCell differentiationB cellsChain pairsCell receptor repertoirePeripheral B cellsReceptor specificityTime cellsMajor forceCell fractionCellsAdaptive immune responsesRepertoireConventional B cellsAvailable repertoireSelection stepImmune responseB cell fractionsSignificant skewing