1999
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
Bibb J, Snyder G, Nishi A, Yan Z, Meijer L, Fienberg A, Tsai L, Kwon Y, Girault J, Czernik A, Huganir R, Hemmings H, Nairn A, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 1999, 402: 669-671. PMID: 10604473, DOI: 10.1038/45251.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCDC2 Protein KinaseCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase 5Cyclin-Dependent KinasesDopamineDopamine and cAMP-Regulated Phosphoprotein 32Enzyme InhibitorsIn Vitro TechniquesMiceNerve Tissue ProteinsNeuronsPhosphoproteinsPhosphorylationRecombinant ProteinsSignal TransductionThreonineConceptsProtein kinase APhospho-ThrDARPP-32Serine/threonine phosphataseSerine/threonine kinaseInhibitor of PKAProtein phosphatase 1Signal transduction moleculesParticular amino acid residuesSignal transduction mechanismsAmino acid residuesCyclin-dependent kinase 5Threonine phosphataseThreonine 75PKA substratesThreonine kinasePhosphatase 1Phosphatase inhibitorProtein kinaseTransduction moleculesKinase ASingle proteinKinase 5Transduction mechanismsKinase
1988
Protein kinases 1988: a current perspective
Blackshear P, Nairn A, Kuo J. Protein kinases 1988: a current perspective. The FASEB Journal 1988, 2: 2957-2969. PMID: 2972578, DOI: 10.1096/fasebj.2.14.2972578.Peer-Reviewed Original ResearchConceptsProtein tyrosine kinasesProtein kinaseIntrinsic protein tyrosine kinase activityProtein serine/threonine kinaseKinase activityTyrosine kinaseCalcium/calmodulin-dependent protein kinaseSerine/threonine kinaseCalmodulin-dependent protein kinaseProtein tyrosine kinase activityPhosphatidylinositol kinase activityNew enzyme speciesTyrosine kinase activityMyosin light chain kinaseCalmodulin kinase IIPseudosubstrate prototopeKinase IIIThreonine kinaseSignal transductionLight chain kinaseConstitutive inhibitorGrowth factor receptorKinase autophosphorylationSubstrate specificityCalcium-calmodulin kinase II