2009
GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches
Young SZ, Bordey A. GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches. Physiology 2009, 24: 171-185. PMID: 19509127, PMCID: PMC2931807, DOI: 10.1152/physiol.00002.2009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdult Stem CellsAnimalsCell DivisionEmbryonic Stem CellsGamma-Aminobutyric AcidHumansNeoplasmsSignal TransductionConceptsStem cellsGamma-amino butyric acidProliferation of pluripotentAdult stem cellsNeural stem cellsAdult tissuesCancer cell proliferationRegulation of secretionTumor stem cellsTumor cellsCell proliferationAdult neuralProliferationCellsGABA controlPeripheral organsGABAergic signalingPeripheral nichesNervous systemMitotic activityPluripotentButyric acidNicheSignalingRegulationGABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation
Dave KA, Bordey A. GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation. IUBMB Life 2009, 61: 496-503. PMID: 19391160, PMCID: PMC2675662, DOI: 10.1002/iub.185.Peer-Reviewed Original ResearchMeSH KeywordsCalciumCell ProliferationCells, CulturedCerebellar NeoplasmsCerebellumGamma-Aminobutyric AcidGlutamic AcidHumansMedulloblastomaReceptors, GABA-ASignal TransductionConceptsGamma-aminobutyric acidRole of GABAVertebrate central nervous systemComplement of receptorsCerebellar granule cell precursorsCell precursorsGranule cell precursorsDevelopmental processesMetabotropic glutamate receptorsCentral nervous systemCell proliferationAdult mammalsNovel targetAmino acid glutamatePharmacological regulationCurrent knowledgeGlutamate receptorsNeural cancersNervous systemCerebellar tumorsCalcium increaseReceptorsProliferationMammalsNovel data
2008
Control of neuroblast production and migration by converging GABA and glutamate signals in the postnatal forebrain
Platel J, Dave KA, Bordey A. Control of neuroblast production and migration by converging GABA and glutamate signals in the postnatal forebrain. The Journal Of Physiology 2008, 586: 3739-3743. PMID: 18467361, PMCID: PMC2538924, DOI: 10.1113/jphysiol.2008.155325.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAdult Stem CellsCell DifferentiationCell MovementCell ProliferationGamma-Aminobutyric AcidGlutamic AcidHumansNeuronsNeurotransmitter AgentsProsencephalonConceptsNeuroblast productionGlutamate receptorsStem cellsSteady-state levelsAdult-born neuronsNovel epigenetic controlNeural stem cellsImmature neuronsAdult neurogenesisNeurotransmitter GABAOlfactory bulbPostnatal forebrainNeuron productionNew steady-state levelStem cell proliferationHigh-affinity uptake systemCalcium elevationNeurotransmitter releaseEpigenetic controlExtracellular concentrationGlutamate signalsGABANegative feedback controlNeuroblast numbersIntercellular signaling
2007
GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis
Platel JC, Lacar B, Bordey A. GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis. Journal Of Molecular Histology 2007, 38: 303-311. PMID: 17554632, PMCID: PMC2556597, DOI: 10.1007/s10735-007-9103-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSubventricular zoneOlfactory bulb interneuronsGABAergic signalingGlutamate receptorsBulb interneuronsForebrain neurogenesisAMPA/kainate receptorsMetabotropic glutamate receptorsNeurogenic subventricular zoneRole of glutamateHomeostatic controlIonotropic glutamate receptorsEmbryonic cortical developmentSVZ neuroblastsNeurotransmitter GABASVZ cellsCortical developmentKainate receptorsGABA transporter subtypesNeurotransmitter glutamateGABA clearanceGABATransporter subtypesReceptorsInterneurons
2006
Enigmatic GABAergic networks in adult neurogenic zones
Bordey A. Enigmatic GABAergic networks in adult neurogenic zones. Brain Research Reviews 2006, 53: 124-134. PMID: 16949673, DOI: 10.1016/j.brainresrev.2006.07.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsBrainCell DifferentiationGamma-Aminobutyric AcidHumansNerve NetNeuronal PlasticityNeuronsParacrine CommunicationSignal TransductionStem CellsConceptsAdult neurogenic zonesNeurogenic zonesGABAergic networksGABAergic signalingAdult neurogenic regionsGABA actionSubventricular zoneNeuronal activityNeurogenic regionsReceptor activationImmature cellsProgenitor cellsUnique cellular propertiesNetwork activitySignalingCellsCellular propertiesReview
2005
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors
Liu X, Wang Q, Haydar TF, Bordey A. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nature Neuroscience 2005, 8: 1179-1187. PMID: 16116450, PMCID: PMC1380263, DOI: 10.1038/nn1522.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBotulinum ToxinsBromodeoxyuridineCadmiumCell CountCell ProliferationChelating AgentsCyclooxygenase InhibitorsDose-Response Relationship, DrugDose-Response Relationship, RadiationDrug InteractionsEgtazic AcidElectric StimulationEnzyme InhibitorsGABA AntagonistsGamma-Aminobutyric AcidGene Expression RegulationGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsImmunohistochemistryIn Vitro TechniquesLateral VentriclesMeclofenamic AcidMembrane PotentialsMiceMice, TransgenicNeuronsNickelPatch-Clamp TechniquesPotassiumSodium Channel BlockersSpider VenomsStem CellsTetrodotoxinConceptsPostnatal subventricular zoneGFAP-expressing cellsSubventricular zoneCell cycleGABAA receptorsStem cellsNeuroblastsProgenitorsGlial fibrillary acidic proteinSVZ cellsGABAA receptor currentsGABAA receptor activationFibrillary acidic proteinReceptor activationCellsProliferationGABA releaseMouse slicesLocal cuesAcidic proteinReceptor currentsSpontaneous depolarizationsGFAPGABAReceptorsAssays for measuring extracellular GABA levels and cell migration rate in acute slices
Bolteus AJ, Garganta C, Bordey A. Assays for measuring extracellular GABA levels and cell migration rate in acute slices. Brain Research 2005, 14: 126-134. PMID: 15721818, DOI: 10.1016/j.brainresprot.2004.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological AssayCell MovementGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidImmunohistochemistryLateral VentriclesMass SpectrometryMembrane Transport ModulatorsMembrane Transport ProteinsMiceMicroscopy, VideoNeurochemistryNeuronsOrgan Culture TechniquesReceptors, GABAStem CellsTelencephalonConceptsRostral migratory streamSubventricular zoneEndogenous GABAGABA levelsGABA receptorsNeuronal precursorsCell migrationLocal GABA levelsExtracellular GABA levelsAcute brain slicesAdult rodent brainPostnatal subventricular zoneFuture therapeutic useNeuronal precursor migrationAcute slicesBrain slicesNeurotransmitter GABASVZ cellsOlfactory bulbRodent brainRMS explantsMigratory streamTherapeutic useNeural precursorsGABA
2004
GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone
Bolteus AJ, Bordey A. GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone. Journal Of Neuroscience 2004, 24: 7623-7631. PMID: 15342728, PMCID: PMC6729616, DOI: 10.1523/jneurosci.1999-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBicucullineBiological TransportBrainCalcium SignalingCell MovementGABA Plasma Membrane Transport ProteinsGABA-A Receptor AgonistsGamma-Aminobutyric AcidMass SpectrometryMembrane Transport ProteinsMiceMicroscopy, VideoNeuronsPatch-Clamp TechniquesPotassiumReceptors, GABA-AStem CellsConceptsAstrocyte-like cellsSubventricular zoneNeuronal precursorsPostnatal subventricular zoneNeuronal precursor migrationCell migrationPrecursor migrationPresence of bicucullineEnhancement of GABAAnterior subventricular zoneInhibition of GABARostral migratory streamAmbient GABA levelsApplication of GABASagittal brain slicesAntagonist bicucullineGABA releaseEndogenous GABAGABA levelsBrain slicesAdult miceGABA transporterMigratory streamGABACell depolarizationGlial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons
Huang H, Bordey A. Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons. Journal Of Neuroscience 2004, 24: 5659-5669. PMID: 15215288, PMCID: PMC6729224, DOI: 10.1523/jneurosci.1338-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid Transport System X-AGAnimalsAntiportersCalciumCerebellumCystineEvoked PotentialsGamma-Aminobutyric AcidGlutamic AcidIn Vitro TechniquesMiceNerve FibersNeural InhibitionNeurogliaPatch-Clamp TechniquesPurkinje CellsReceptors, N-Methyl-D-AspartateReceptors, PresynapticRyanodineSynaptic TransmissionConceptsGlial glutamate transportersMiniature IPSCsPurkinje neuronsGlutamate transportersSpontaneous IPSCsSynaptic inhibitionInhibitory synapsesNMDAR activationWhole-cell patch-clamp recordingsPresynaptic NMDA receptorsPaired-pulse ratioMouse cerebellar slicesNMDA receptor activationPresynaptic NMDA receptor activationPatch-clamp recordingsBergmann glial cellsBeta-benzyloxyaspartic acidAdjacent Purkinje neuronsCystine-glutamate antiporterMIPSC frequencyGABAergic terminalsGABAergic synapsesGlial cellsNMDA receptorsExcitatory synapses
2003
GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation
Wang DD, Krueger DD, Bordey A. GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation. The Journal Of Physiology 2003, 550: 785-800. PMID: 12807990, PMCID: PMC2343064, DOI: 10.1113/jphysiol.2003.042572.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBarbituratesBenzodiazepinesCerebral VentriclesDose-Response Relationship, DrugElectrophysiologyGABA AntagonistsGamma-Aminobutyric AcidGlutamate DecarboxylaseIsoenzymesMembrane PotentialsMiceNeostriatumNeuronsPatch-Clamp TechniquesPicrotoxinPotassium ChannelsReceptors, GABA-AStem CellsZincConceptsRostral migratory streamGABAA receptor activationSubventricular zoneNeuronal progenitorsReceptor activationGlutamic acid decarboxylase 67Resting potentialsPostnatal mammalian brainPatch-clamp recordingsSVZ/RMSMouse brain slicesRecorded cellsCell-attached patchesGABA responsesBrain slicesNeurotransmitter GABASubset of progenitorsBenzodiazepine agonistsEmbryonic neuronsAction potentialsMammalian brainMigratory streamGABAInverse agonistSpecific receptors
2002
GAT-1 and Reversible GABA Transport in Bergmann Glia in Slices
Barakat L, Bordey A. GAT-1 and Reversible GABA Transport in Bergmann Glia in Slices. Journal Of Neurophysiology 2002, 88: 1407-1419. PMID: 12205162, DOI: 10.1152/jn.2002.88.3.1407.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCarrier ProteinsCerebellumElectrophysiologyGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidIn Vitro TechniquesMembrane ProteinsMembrane Transport ProteinsNeurogliaOrganic Anion TransportersPatch-Clamp TechniquesRatsRats, Sprague-DawleyReceptors, GABA-AConceptsGAT-1Bergmann gliaInward currentsGABA transporterWhole-cell patch-clamp recordingsCell patch-clamp recordingsGlial GABA uptakePatch-clamp recordingsRat cerebellar slicesGABA perfusionReceptor blockersAmbient GABANNC-711Extracellular GABAGABA effluxGABA uptakeGABA receptorsCerebellar slicesGAT subtypesNipecotic acidReceptor activationGABABlockersGliaOutward currents