2023
Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R‐associated proteins and downstream pathways
Lafourcade C, Sparks F, Bordey A, Wyneken U, Mohammadi M. Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R‐associated proteins and downstream pathways. Epilepsia 2023, 64: 1432-1443. PMID: 36869624, DOI: 10.1111/epi.17569.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCannabinoidsDentate GyrusDisease Models, AnimalEpilepsyEpilepsy, Temporal LobeHippocampusHumansNeuronsSeizuresStatus EpilepticusConceptsTemporal lobe epilepsyDentate gyrusStatus epilepticusProgression of epileptogenesisHippocampal dentate gyrusRole of CB1RCannabinoid regulationHippocampal excitabilityRecurrent seizuresLobe epilepsyRecent findingsEndogenous cannabinoidsBrain injuryClinical trialsEpileptic dischargesNeurologic disordersRetrograde messengerDG circuitryHippocampal formationNeuronal activityTherapeutic interventionsSeizuresEpileptogenesisExcessive excitationCannabinoids
2004
Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis
Bordey A, Spencer DD. Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis. Epilepsy Research 2004, 59: 107-122. PMID: 15246115, DOI: 10.1016/j.eplepsyres.2004.04.004.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyGlial cellsCA1 regionHilar astrocytesPutative astrocytesIntractable temporal lobe epilepsySclerotic human hippocampusTemporal lobe sclerosisNon-sclerotic hippocampiPatch-clamp recordingsIntercellular couplingSuch patientsEpileptic hippocampusLobe epilepsyCell-attached patchesPatient groupElectrophysiological alterationsDentate gyrusEpileptic humansChannel expressionAstrocytesElectrophysiological propertiesHippocampusTumor casesHuman hippocampus
2003
Chemokine modulation of high‐conductance Ca2+‐sensitive K+ currents in microglia from human hippocampi
Bordey A, Spencer DD. Chemokine modulation of high‐conductance Ca2+‐sensitive K+ currents in microglia from human hippocampi. European Journal Of Neuroscience 2003, 18: 2893-2898. PMID: 14656339, DOI: 10.1111/j.1460-9568.2003.03021.x.Peer-Reviewed Original ResearchConceptsHigh-conductance Ca2MIP1-alphaAcute pathological processesNon-activated microgliaSensitive outward currentsPharmaco-resistant epilepsyPatch-clamp recordingsOutward current amplitudeHigh input resistanceChemokine modulationHippocampal slicesInjury siteBrain slicesChronic pathologiesMicrogliaEpileptic patientsAmeboid morphologyIntracellular Ca2Human hippocampusOutward currentsMigratory effectsInput resistancePositive labelingPathological processesMode of action
1998
Properties of human glial cells associated with epileptic seizure foci
Bordey A, Sontheimer H. Properties of human glial cells associated with epileptic seizure foci. Epilepsy Research 1998, 32: 286-303. PMID: 9761328, DOI: 10.1016/s0920-1211(98)00059-x.Peer-Reviewed Original ResearchConceptsSeizure focusGlial cellsMesio-temporal lobe epilepsyWhole-cell patch-clamp recordingsLucifer YellowControl rat hippocampusPathophysiology of seizuresSlow action potentialsCurrent-clamp studiesGFAP-positive astrocytesEpileptic seizure fociPatch-clamp recordingsHuman glial cellsLobe epilepsyAcute slicesRat hippocampusEpilepsy patientsClamp studiesRat astrocytesAstrocytesIntermediate filaments GFAPNormal astrocytesAction potentialsPhysiological propertiesBranched processes