2017
Valnoctamide Inhibits Cytomegalovirus Infection in Developing Brain and Attenuates Neurobehavioral Dysfunctions and Brain Abnormalities
Ornaghi S, Hsieh LS, Bordey A, Vergani P, Paidas MJ, van den Pol AN. Valnoctamide Inhibits Cytomegalovirus Infection in Developing Brain and Attenuates Neurobehavioral Dysfunctions and Brain Abnormalities. Journal Of Neuroscience 2017, 37: 6877-6893. PMID: 28630251, PMCID: PMC5518418, DOI: 10.1523/jneurosci.0970-17.2017.Peer-Reviewed Original ResearchConceptsAnti-CMV drugsBrain defectsNeurological outcomeCMV replicationMouse brainAvailable anti-CMV drugsHuman fetal brain cellsLong-term neurological outcomeTreatment of cytomegalovirusAdverse neurological outcomesUninfected control miceCommon infectious causeLong-term motorSecond trimester human fetusesUninfected control animalsFetal brain cellsHuman fetal astrocytesJuvenile male miceWeeks of lifeAdverse side effectsEfficacious therapeutic effectsDetectable adverse effectsNewborn mouse brainLevels of virusCMV infection
2013
A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits
Feliciano DM, Lin TV, Hartman NW, Bartley CM, Kubera C, Hsieh L, Lafourcade C, O'Keefe RA, Bordey A. A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits. International Journal Of Developmental Neuroscience 2013, 31: 667-678. PMID: 23485365, PMCID: PMC3830611, DOI: 10.1016/j.ijdevneu.2013.02.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCentral Nervous SystemCognition DisordersDisease Models, AnimalEpilepsyHumansMiceTOR Serine-Threonine KinasesTuberous SclerosisConceptsTuberous sclerosis complexCortical lesionsBrain lesionsLoss of heterozygosityNeuronal functionNovel therapeutic targetNeuronal circuit formationMolecular mechanisms downstreamRecent mouse modelsNeurological manifestationsNeurological presentationTSC patientsBenign tumorsBrain malformationsDiscrete lesionsMouse modelNeuropsychiatric problemsTherapeutic targetSynaptic plasticityPerinatal developmentCircuit formationLesionsMTOR hyperactivityNeurocognitive deficitsPsychological impairment