2000
Muscarinic Activation of BK Channels Induces Membrane Oscillations in Glioma Cells and Leads to Inhibition of Cell Migration
Bordey A, Sontheimer H, Trouslard J. Muscarinic Activation of BK Channels Induces Membrane Oscillations in Glioma Cells and Leads to Inhibition of Cell Migration. The Journal Of Membrane Biology 2000, 176: 31-40. PMID: 10882426, DOI: 10.1007/s00232001073.Peer-Reviewed Original ResearchConceptsPatch-clamp recordingsGlioma cellsAstrocytoma cellsCell migrationCultured human astrocytoma cellsIntracellular free calcium concentrationACh receptor agonistsFree calcium concentrationHuman astrocytoma cellsRelease of Ca2Glioma cell migrationMuscarinic activationMuscarinic antagonistCerebral tumorsMuscarinic receptorsReceptor agonistBath applicationActivate Ca2Intracellular injectionCerebrospinal fluidACh applicationAcetylcholineBiphasic increaseIntracellular storesExternal calcium
1996
Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices.
Bordey A, Feltz P, Trouslard J. Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices. The Journal Of Physiology 1996, 497: 175-187. PMID: 8951720, PMCID: PMC1160921, DOI: 10.1113/jphysiol.1996.sp021758.Peer-Reviewed Original ResearchConceptsSpontaneous excitatory postsynaptic currentsCentral autonomic areaSympathetic preganglionic neuronesSpinal cord slicesGlutamate-induced currentsAutonomic areasCord slicesTransverse thoracolumbar spinal cord slicesAgonist rank order potencyAction potentialsRat spinal cord slicesWhole-cell patch-clamp techniqueNicotinic acetylcholine receptor agonistExcitatory synaptic activityPresence of tetrodotoxinAcetylcholine receptor agonistExcitatory postsynaptic currentsMembrane current noisePatch-clamp techniqueCurrent-clamp conditionsDetectable current responseRank order potencySEPSC amplitudeVoltage-clamp conditionsStrong inward rectification