2023
Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R‐associated proteins and downstream pathways
Lafourcade C, Sparks F, Bordey A, Wyneken U, Mohammadi M. Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R‐associated proteins and downstream pathways. Epilepsia 2023, 64: 1432-1443. PMID: 36869624, DOI: 10.1111/epi.17569.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyDentate gyrusStatus epilepticusProgression of epileptogenesisHippocampal dentate gyrusRole of CB1RCannabinoid regulationHippocampal excitabilityRecurrent seizuresLobe epilepsyRecent findingsEndogenous cannabinoidsBrain injuryClinical trialsEpileptic dischargesNeurologic disordersRetrograde messengerDG circuitryHippocampal formationNeuronal activityTherapeutic interventionsSeizuresEpileptogenesisExcessive excitationCannabinoids
2021
Treating Seizures With Low-Frequency Electrical Stimulation
Bordey A. Treating Seizures With Low-Frequency Electrical Stimulation. Epilepsy Currents 2021, 21: 197-198. PMID: 34867103, PMCID: PMC8609597, DOI: 10.1177/15357597211003559.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMesial temporal lobe epilepsyLow-frequency stimulationTemporal lobe epilepsyLobe epilepsySeizure generationMouse modelElectrical low-frequency stimulationHippocampal low-frequency stimulationFrequency electrical stimulationHippocampal sclerosisSclerotic hippocampusSeizure controlSeizure generalizationGeneralized seizuresSpontaneous seizuresPharmacoresistant epilepsyDaily stimulationGranule cellsElectrical stimulationEpilepsySeizuresCommon formStimulationHippocampusSlice experiments
2004
Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis
Bordey A, Spencer DD. Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis. Epilepsy Research 2004, 59: 107-122. PMID: 15246115, DOI: 10.1016/j.eplepsyres.2004.04.004.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyGlial cellsCA1 regionHilar astrocytesPutative astrocytesIntractable temporal lobe epilepsySclerotic human hippocampusTemporal lobe sclerosisNon-sclerotic hippocampiPatch-clamp recordingsIntercellular couplingSuch patientsEpileptic hippocampusLobe epilepsyCell-attached patchesPatient groupElectrophysiological alterationsDentate gyrusEpileptic humansChannel expressionAstrocytesElectrophysiological propertiesHippocampusTumor casesHuman hippocampus