2013
A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits
Feliciano DM, Lin TV, Hartman NW, Bartley CM, Kubera C, Hsieh L, Lafourcade C, O'Keefe RA, Bordey A. A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits. International Journal Of Developmental Neuroscience 2013, 31: 667-678. PMID: 23485365, PMCID: PMC3830611, DOI: 10.1016/j.ijdevneu.2013.02.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTuberous sclerosis complexCortical lesionsBrain lesionsLoss of heterozygosityNeuronal functionNovel therapeutic targetNeuronal circuit formationMolecular mechanisms downstreamRecent mouse modelsNeurological manifestationsNeurological presentationTSC patientsBenign tumorsBrain malformationsDiscrete lesionsMouse modelNeuropsychiatric problemsTherapeutic targetSynaptic plasticityPerinatal developmentCircuit formationLesionsMTOR hyperactivityNeurocognitive deficitsPsychological impairment
2001
Electrophysiological Characteristics of Reactive Astrocytes in Experimental Cortical Dysplasia
Bordey A, Lyons SA, Hablitz JJ, Sontheimer H. Electrophysiological Characteristics of Reactive Astrocytes in Experimental Cortical Dysplasia. Journal Of Neurophysiology 2001, 85: 1719-1731. PMID: 11287494, DOI: 10.1152/jn.2001.85.4.1719.Peer-Reviewed Original ResearchConceptsGap junction couplingReactive gliosisFreeze lesionGlial fibrillary acidic protein immunoreactivityWhole-cell patch-clamp recordingsCell patch-clamp recordingsExperimental cortical dysplasiaCortical layers IPatch-clamp recordingsPostnatal day 16Reduced gap junction couplingNormal neuronal functionDysplastic neocortexP24 ratsDysplastic cortexReactive astrocytesCortical dysplasiaNeuronal dysfunctionProtein immunoreactivityElectrophysiological characteristicsAstrocytesChannel expressionNeuronal functionMicrosulcusLayer I