2012
Understanding the Etiology of Tuberous Sclerosis Complex
Bordey A. Understanding the Etiology of Tuberous Sclerosis Complex. 2012 DOI: 10.21236/ada566455.Peer-Reviewed Original ResearchTuberous sclerosis complexTSC lesionsAnimal modelsDiscrete cortical lesionsGenetic multisystem disorderSevere neurological symptomsTsc1 inactivationCortical hyperexcitabilityNeurological symptomsCortical lesionsPerinatal lifeTSC patientsSeizure generationMultisystem disorderFormation of lesionsSignificant causeLesionsLesion formationEtiologyDisordersNovel technical approachHyperexcitabilityMorbidityPatientsSymptoms
2011
Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion
Feliciano DM, Quon JL, Su T, Taylor MM, Bordey A. Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion. Human Molecular Genetics 2011, 21: 799-810. PMID: 22068588, PMCID: PMC3263992, DOI: 10.1093/hmg/ddr511.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell MovementCerebral CortexDendritesElectroporationFemaleGene DeletionMaleMiceMice, TransgenicNeurogenesisNeurogliaNeuronsOlfactory BulbPeriventricular Nodular HeterotopiaSingle-Cell AnalysisTOR Serine-Threonine KinasesTuberous SclerosisTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsConceptsTuberous sclerosis complexSubventricular zoneBrain lesionsPostnatal subventricular zoneForebrain structuresTsc1 deletionHuman subventricular zoneCortical infiltrationNeurological symptomsNeuropsychiatric symptomsNon-invasive imagingOlfactory lesionsPostnatal neurogenesisTSC patientsPersistent infiltrationTransgenic miceAbnormal circuitsStructural abnormalitiesDendritic treeNeuronal precursorsLesionsEmbryonic neurogenesisNeurogenesisNeuronsMicronodules