2016
Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice
Mahoney C, Feliciano DM, Bordey A, Hartman NW. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neuroscience Letters 2016, 614: 112-118. PMID: 26812181, DOI: 10.1016/j.neulet.2015.12.042.Peer-Reviewed Original ResearchConceptsNeural stem cellsSubventricular zoneNeonatal subventricular zoneWeek old miceTuberous sclerosis complexStem cellsNewborn neuroblastsYoung miceOld miceProgressive lossYoung adultsRapamycin complex 1Mechanistic targetRecent evidenceProliferative cellsMiceHyperactive mTORC1Terminal differentiationCellsMTORC1 activationProliferationActivationMTORC1NeurogenesisHyperactivity
2013
Postnatal Neurogenesis in the Subventricular Zone: A Manipulable Source for CNS Plasticity and Repair
Pathania M, Bordey A. Postnatal Neurogenesis in the Subventricular Zone: A Manipulable Source for CNS Plasticity and Repair. 2013 DOI: 10.5772/55679.Books
2012
Newborn cortical neurons: only for neonates?
Feliciano DM, Bordey A. Newborn cortical neurons: only for neonates? Trends In Neurosciences 2012, 36: 51-61. PMID: 23062965, PMCID: PMC3534801, DOI: 10.1016/j.tins.2012.09.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2011
Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion
Feliciano DM, Quon JL, Su T, Taylor MM, Bordey A. Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion. Human Molecular Genetics 2011, 21: 799-810. PMID: 22068588, PMCID: PMC3263992, DOI: 10.1093/hmg/ddr511.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell MovementCerebral CortexDendritesElectroporationFemaleGene DeletionMaleMiceMice, TransgenicNeurogenesisNeurogliaNeuronsOlfactory BulbPeriventricular Nodular HeterotopiaSingle-Cell AnalysisTOR Serine-Threonine KinasesTuberous SclerosisTuberous Sclerosis Complex 1 ProteinTumor Suppressor ProteinsConceptsTuberous sclerosis complexSubventricular zoneBrain lesionsPostnatal subventricular zoneForebrain structuresTsc1 deletionHuman subventricular zoneCortical infiltrationNeurological symptomsNeuropsychiatric symptomsNon-invasive imagingOlfactory lesionsPostnatal neurogenesisTSC patientsPersistent infiltrationTransgenic miceAbnormal circuitsStructural abnormalitiesDendritic treeNeuronal precursorsLesionsEmbryonic neurogenesisNeurogenesisNeuronsMicronodulesNeurotransmitters couple brain activity to subventricular zone neurogenesis
Young SZ, Taylor MM, Bordey A. Neurotransmitters couple brain activity to subventricular zone neurogenesis. European Journal Of Neuroscience 2011, 33: 1123-1132. PMID: 21395856, PMCID: PMC3075963, DOI: 10.1111/j.1460-9568.2011.07611.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSVZ cell proliferationSubventricular zoneHippocampal subgranular zoneMultiple neurotransmitter systemsSubventricular zone neurogenesisCell proliferationSpecific brain regionsSVZ proliferationSubgranular zoneAdult neurogenesisΓ-aminobutyric acidDentate gyrusLateral ventricleNeurotransmitter systemsDrug treatmentNeuronal projectionsPrivileged microenvironmentAlzheimer's diseaseBrain regionsNeurogenesisCell therapyDiseaseBrain activityProliferationSeizures
2010
NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network
Platel JC, Dave KA, Gordon V, Lacar B, Rubio ME, Bordey A. NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network. Neuron 2010, 65: 859-872. PMID: 20346761, PMCID: PMC2861893, DOI: 10.1016/j.neuron.2010.03.009.Peer-Reviewed Original ResearchConceptsAdult-born neuronsNMDA receptorsNMDAR activitySynaptic networksNeuroblast survivalGlutamate release machineryAstrocyte-like cellsLoss of neuroblastsNeonatal electroporationSpecialized astrocytesAstrocytic glutamateOlfactory bulbVesicular releaseRelease machineryReceptorsNeuroblastsNeuronsIntercellular mechanismsSurvivalGlutamateNeuroblast apoptosisAstrocytesNeurogenesisNeurotransmittersSVZNeurotransmitter signaling in postnatal neurogenesis: The first leg
Platel JC, Stamboulian S, Nguyen I, Bordey A. Neurotransmitter signaling in postnatal neurogenesis: The first leg. Brain Research Reviews 2010, 63: 60-71. PMID: 20188124, PMCID: PMC2862802, DOI: 10.1016/j.brainresrev.2010.02.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFate determinationSonic hedgehogNeurotransmitter signalingDifferent cell typesSubventricular zoneMultitude of receptorsMaster regulatorGenetic signaturesMosaic natureGamma-aminobutyric acidMicroenvironmental signalsCell typesIntracellular pathwaysAstrocyte-like cellsFunction of neurotransmittersHedgehogSignalingNeurogenesisNeurogenic zonesAdult brainPostnatal neurogenesisPeripheral organsNeurotransmitter functionSynaptic integrationGenesA symphony of signals conducts early and late stages of adult neurogenesis
Pathania M, Yan LD, Bordey A. A symphony of signals conducts early and late stages of adult neurogenesis. Neuropharmacology 2010, 58: 865-876. PMID: 20097213, PMCID: PMC2850602, DOI: 10.1016/j.neuropharm.2010.01.010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPoint of regulationCentral nervous systemMammalian central nervous systemCell-intrinsic mechanismsDifferent regulatory factorsFate commitmentNiche microenvironmentEarly neurogenesisIntracellular machineryRegulatory factorsIsolated nichesLate neurogenesisExtrinsic factorsNeurogenesisMature networksAdult neurogenesisDendritic developmentSynaptic integrationIntrinsic factorsNervous systemLater stagesNicheMachineryNeurotransmittersNetwork activity
2006
Adult Neurogenesis: Basic Concepts of Signaling
Bordey A. Adult Neurogenesis: Basic Concepts of Signaling. Cell Cycle 2006, 5: 722-728. PMID: 16582623, DOI: 10.4161/cc.5.7.2614.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdult neurogenesisMotor memory formationBrain injuryPersistent neurogenesisNeurogenic environmentAdult brainNeurogenic regionsNeuroglial networksNeurogenesisEmbryonic neurogenesisIntegrative propertiesMemory formationExtracellular matrix moleculesCell communicationBrainRecent findingsCellsExamples of cellsMatrix moleculesInjuryNonsynaptic GABAergic Communication and Postnatal Neurogenesis
Liu X, Bolteus A, Bordey A. Nonsynaptic GABAergic Communication and Postnatal Neurogenesis. Contemporary Neuroscience 2006, 95-104. DOI: 10.1007/978-1-59745-021-8_9.ChaptersFunction of GABASubventricular zonePostnatal neurogenesisNeuronal precursorsNeuron-glial networksSVZ stem cellsStem cellsNeural stem cellsLocal GABAergicNonsynaptic communicationGABAergic systemSynaptic contactsΓ-aminobutyric acidSVZ cellsSVZ precursorsSubependymal zoneGABANeurogenesisCell proliferationCellsEmbryonic cell proliferationGABAergicBrain
2005
The Postnatal Subventricular Zone: A Source of New Cells in This Old Brain
Bordey A. The Postnatal Subventricular Zone: A Source of New Cells in This Old Brain. Nepal Journal Of Neuroscience 2005, 2: 12-23. DOI: 10.3126/njn.v2i1.19977.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSubventricular zoneNon-synaptic communicationLarge germinal centersHigher cognitive centersRostral migratory streamPostnatal subventricular zoneBrain injuryPersistent neurogenesisLateral ventricleOlfactory bulbAdult brainGerminal centersOld brainMigratory streamCognitive centersNeurogenesisLateral wallStem cellsSVZBrainFuture strategiesNeuroblastsNepal JournalIntercellular signalingCells