2016
Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels
Zhang L, Huang T, Bordey A. Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Neuroscience Letters 2016, 629: 15-18. PMID: 27345385, PMCID: PMC4983256, DOI: 10.1016/j.neulet.2016.06.037.Peer-Reviewed Original ResearchConceptsTuberous sclerosis complexDendritic complexityDendritic patterningTotal dendritic lengthTsc1 haploinsufficiencyFLNA levelsNeonatal electroporationDendritic lengthNewborn neuronsDendritic abnormalitiesSholl analysisOlfactory bulbFilamin ATsc1 lossHeterozygote miceCognitive defectsDendritic morphologyMiceA levelsMost individualsHaploinsufficiencyHeterozygote conditionLevelsAbnormalitiesNeurons
2015
Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis
Zhang L, Feliciano DM, Huang T, Zhang S, Bordey A. Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis. Neuroscience Letters 2015, 612: 43-47. PMID: 26655465, PMCID: PMC4728030, DOI: 10.1016/j.neulet.2015.11.038.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor 1aTuberous sclerosis complexDendritic complexityOlfactory bulb neuronsNeonatal electroporationBulb neuronsTuberous sclerosisTransgenic miceTSC neuronsDendritic patterningNeurological disordersNeuronsCellular alterationsDendritic overgrowthPathological conditionsMRNA levelsRapamycin complex 1Mechanistic targetCognitive disabilitiesData highlightTranscriptional activityVivoFactor 1AOvergrowthLevel contributes
2012
Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone
Lacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone. Journal Of Neuroscience 2012, 32: 16435-16448. PMID: 23152626, PMCID: PMC3520061, DOI: 10.1523/jneurosci.1457-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornAstrocytesCalcium SignalingCapillariesCerebral VentriclesCerebrovascular CirculationElectric StimulationElectroporationFemaleFluorescent Antibody TechniqueImage Processing, Computer-AssistedLaser-Doppler FlowmetryMaleMiceMuscle TonusMuscle, Smooth, VascularNeural Stem CellsPericytesVasoconstrictionVasodilationConceptsNeural progenitor cellsSubventricular zoneB cellsBlood flowSVZ cellsPurinergic receptorsPostnatal subventricular zoneVascular responsesCapillary constrictionTransgenic miceElectrical stimulationCalcium increaseBlood flow increasesLaser Doppler flowmetryCapillary blood flowAstrocyte-like cellsReceptor agonist UTPNeonatal electroporationNeurometabolic couplingIntraventricular injectionVasodilating factorsAcute slicesYoung miceDoppler flowmetryHemodynamic response
2011
Gap junction‐mediated calcium waves define communication networks among murine postnatal neural progenitor cells
Lacar B, Young SZ, Platel J, Bordey A. Gap junction‐mediated calcium waves define communication networks among murine postnatal neural progenitor cells. European Journal Of Neuroscience 2011, 34: 1895-1905. PMID: 22098557, PMCID: PMC3237798, DOI: 10.1111/j.1460-9568.2011.07901.x.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsNeurogenic nicheB2 cellsBlood vesselsCalcium wavesPurinergic receptor blockerProgenitor cellsPostnatal neurogenic nichesFunctional couplingPostnatal neural progenitor cellsGap junction blockersGap junction protein connexin 43Neonatal electroporationNiche astrocytesReceptor blockersProtein connexin 43Intercellular calcium wavesSubventricular zoneCells persistJunction blockersB1 cellsB cellsDye couplingDistinct entityConnexin 43
2010
NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network
Platel JC, Dave KA, Gordon V, Lacar B, Rubio ME, Bordey A. NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network. Neuron 2010, 65: 859-872. PMID: 20346761, PMCID: PMC2861893, DOI: 10.1016/j.neuron.2010.03.009.Peer-Reviewed Original ResearchConceptsAdult-born neuronsNMDA receptorsNMDAR activitySynaptic networksNeuroblast survivalGlutamate release machineryAstrocyte-like cellsLoss of neuroblastsNeonatal electroporationSpecialized astrocytesAstrocytic glutamateOlfactory bulbVesicular releaseRelease machineryReceptorsNeuroblastsNeuronsIntercellular mechanismsSurvivalGlutamateNeuroblast apoptosisAstrocytesNeurogenesisNeurotransmittersSVZ