Featured Publications
Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy
Nguyen LH, Xu Y, Mahadeo T, Zhang L, Lin TV, Born HA, Anderson AE, Bordey A. Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy. Brain 2021, 145: 1310-1325. PMID: 34849602, PMCID: PMC9128821, DOI: 10.1093/brain/awab390.Peer-Reviewed Original ResearchConceptsFocal malformationsCortical developmentJuvenile miceCortical spectral activitySpontaneous seizure frequencyIrregular firing patternNovel therapeutic opportunitiesNeuronal cytomegalySeizure frequencyEpilepsy onsetNeuronal abnormalitiesElectrophysiological alterationsIntractable epilepsyNeuronal dysfunctionJuvenile brainMouse modelMTOR pathwayTherapeutic opportunitiesMalformationsFiring patternsEpilepsyAberrant expressionNeurodevelopmental disordersMTOR effectorsMice
2004
Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis
Bordey A, Spencer DD. Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis. Epilepsy Research 2004, 59: 107-122. PMID: 15246115, DOI: 10.1016/j.eplepsyres.2004.04.004.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyGlial cellsCA1 regionHilar astrocytesPutative astrocytesIntractable temporal lobe epilepsySclerotic human hippocampusTemporal lobe sclerosisNon-sclerotic hippocampiPatch-clamp recordingsIntercellular couplingSuch patientsEpileptic hippocampusLobe epilepsyCell-attached patchesPatient groupElectrophysiological alterationsDentate gyrusEpileptic humansChannel expressionAstrocytesElectrophysiological propertiesHippocampusTumor casesHuman hippocampus