2015
Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development
Nishimura S, Bilgüvar K, Ishigame K, Sestan N, Günel M, Louvi A. Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development. PLOS ONE 2015, 10: e0124295. PMID: 25875176, PMCID: PMC4398320, DOI: 10.1371/journal.pone.0124295.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBone Morphogenetic Protein 7Cell MovementChemokine CXCL12CholecystokininCorpus CallosumEmbryo, MammalianGene Expression ProfilingGene Expression Regulation, DevelopmentalHomozygoteHumansInterneuronsMiceMice, KnockoutMidline Thalamic NucleiMutationNeocortexNeuropilin-2Receptor, Cholecystokinin AReceptor, Cholecystokinin BReceptors, N-Methyl-D-AspartateSignal TransductionTranscriptomeConceptsCCK receptorsBrain developmentMammalian neocortical developmentCentral nervous systemCortical interneuron migrationHomozygous mutant miceMammalian brain developmentPeripheral organsReceptor lossCorpus callosumCortical developmentPostnatal brainAbundant neuropeptideNervous systemInterneuron migrationMutant miceEmbryonic neocortexNeocortical developmentReceptorsPeptide hormonesG proteinsCholecystokininReciprocal expressionCCKBRBrain
2012
Notch and disease: A growing field
Louvi A, Artavanis-Tsakonas S. Notch and disease: A growing field. Seminars In Cell And Developmental Biology 2012, 23: 473-480. PMID: 22373641, PMCID: PMC4369912, DOI: 10.1016/j.semcdb.2012.02.005.Peer-Reviewed Original ResearchConceptsCellular fate choicesAdult stem cellsInvolvement of NotchFate choiceNotch receptorsHuman diseasesNormal developmentPleiotropic fashionStem cellsRational therapeutic avenueBiologyTherapeutic avenuesBroad actionPathwayProfound involvementComplex controlExperimental systemNotchRelated pathologiesCellsReceptorsPathobiology
1997
Insulin-like growth factor II stimulates cell proliferation through the insulin receptor
Morrione A, Valentinis B, Xu S, Yumet G, Louvi A, Efstratiadis A, Baserga R. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 3777-3782. PMID: 9108054, PMCID: PMC20517, DOI: 10.1073/pnas.94.8.3777.Peer-Reviewed Original ResearchConceptsInsulin receptorSerum-free mediumType 1 insulin-like growth factor receptorCell proliferationInsulin-like growth factor receptorR cellsIGF-IIWild-type counterpartsGrowth factor receptorGrowth factor supplementationInsulin-like growth factor IITargeted disruptionFactor receptorGrowth factor IIFactor supplementationGrowth factorPlasmidAdditional plasmidsCellsReceptorsFactor IIProliferationGenesIGF1RFibroblasts